Chiral phosphine oxides successfully catalyze asymmetric cross-aldol reactions of various carbonyl compounds in a highly enantioselective manner. The phosphine oxide catalysts coordinate to chlorosilanes to form chiral hypervalent silicon complexes in situ, which activate both aldol donors and acceptors, thus realizing cross-aldol reactions between a ketone and an aldehyde, between two aldehydes, between two ketones, and of 2,6-diketones. The use of phosphine oxide catalysis can be further extended to achieve the first catalytic enantioselective double aldol reactions, realizing one-pot stereoselective construction of up to four stereogenic centers.
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Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ． Ｐｈａｒｍ． Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2019-06-01","prism:volume":"67","prism:number":"6","prism:startingPage":"519","prism:endingPage":"526"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/029698340"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I029698340"},{"@id":"https://www.jstage.jst.go.jp/article/cpb/67/6/67_c19-00015/_pdf"}],"availableAt":"2019-06-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=aldol%20reaction","dc:title":"aldol reaction"},{"@id":"https://cir.nii.ac.jp/all?q=phosphine%20oxide","dc:title":"phosphine oxide"},{"@id":"https://cir.nii.ac.jp/all?q=tandem%20catalysis","dc:title":"tandem 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