{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390848250116869120.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.20738/johb.33.1_1"}},{"identifier":{"@type":"NAID","@value":"130007854090"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2021088200"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues.\nIn this study, we investigated the impact of SHED-conditioned medium (SHED-CM) on radiation-induced skin injury. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema.\nIntra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410848250116869120","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000409314264"}],"foaf:name":[{"@language":"en","@value":"KAWARABAYASHI Keita"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School"},{"@language":"en","@value":"Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326221000704","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40801626"},{"@type":"NRID","@value":"1000040801626"},{"@type":"NRID","@value":"9000409314265"},{"@type":"NRID","@value":"9000414093272"},{"@type":"NRID","@value":"9000398612001"},{"@type":"NRID","@value":"9000413692933"},{"@type":"NRID","@value":"9000341541192"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/fumiya"}],"foaf:name":[{"@language":"en","@value":"KANO Fumiya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410848250116869125","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000409314266"}],"foaf:name":[{"@language":"en","@value":"HASHIMOTO Noboru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410848250116869124","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000409314267"}],"foaf:name":[{"@language":"en","@value":"HIBI Hideharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral and Maxillofacial Surgery Nagoya University Graduate School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410848250116869122","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000409314268"}],"foaf:name":[{"@language":"en","@value":"IWAMOTO Tsutomu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326221361920","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50244083"},{"@type":"NRID","@value":"1000050244083"},{"@type":"NRID","@value":"9000356489013"},{"@type":"NRID","@value":"9000409314269"},{"@type":"NRID","@value":"9000414354244"},{"@type":"NRID","@value":"9000001730396"},{"@type":"NRID","@value":"9000414093280"},{"@type":"NRID","@value":"9000338666467"},{"@type":"NRID","@value":"9000010223266"},{"@type":"NRID","@value":"9000006872183"},{"@type":"NRID","@value":"9000411774350"},{"@type":"NRID","@value":"9000018842590"},{"@type":"NRID","@value":"9000342455111"},{"@type":"NRID","@value":"9000411000732"},{"@type":"NRID","@value":"9000413692936"},{"@type":"NRID","@value":"9000341541201"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0145306"}],"foaf:name":[{"@language":"en","@value":"YAMAMOTO Akihito"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"21887888"},{"@type":"LISSN","@value":"21887888"},{"@type":"EISSN","@value":"21896682"}],"prism:publicationName":[{"@language":"ja","@value":"Journal of Oral Health and Biosciences"},{"@language":"en","@value":"Journal of Oral Health and Biosciences"}],"dc:publisher":[{"@language":"en","@value":"Shikoku Society of Dental Research"},{"@language":"ja","@value":"四国歯学会"}],"prism:publicationDate":"2020","prism:volume":"33","prism:number":"1","prism:startingPage":"1","prism:endingPage":"7"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2021088200"}],"availableAt":"2020","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Human%20dental%20pulp%20stem%20cells","dc:title":"Human dental pulp stem cells"},{"@id":"https://cir.nii.ac.jp/all?q=conditioned%20media","dc:title":"conditioned media"},{"@id":"https://cir.nii.ac.jp/all?q=mesenchymal%20stem%20cells","dc:title":"mesenchymal stem cells"},{"@id":"https://cir.nii.ac.jp/all?q=Radiation-induced%20skin%20reactions","dc:title":"Radiation-induced skin reactions"},{"@id":"https://cir.nii.ac.jp/all?q=Cutaneous%20radiation%20syndrome","dc:title":"Cutaneous radiation syndrome"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781957835392","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04404"},{"@type":"JGN","@value":"JP17H04404"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04404/"}],"notation":[{"@language":"ja","@value":"歯髄幹細胞由来液性因子による口腔乾燥症の新規治療法の開発"},{"@language":"en","@value":"Development of a novel treatment method for xerostomia by dental pulp stem cell-derived humoral factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782023669888","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K18241"},{"@type":"JGN","@value":"JP19K18241"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18241/"}],"notation":[{"@language":"ja","@value":"ミクログリア由来エクソソームによる神経障害性疼痛のメカニズム解明"},{"@language":"en","@value":"Mechanisms of neuropathic pain elucidated by microglia-derived exosomes"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2007830255"},{"@type":"CIA","@value":"130007854090"},{"@type":"KAKEN","@value":"PRODUCT-23377653"},{"@type":"KAKEN","@value":"PRODUCT-22936113"}]}