Gene expression changes of epigenetic-related genes and spermatogenesis-related gene in the testes of F1 male mice gestationally exposed to arsenic

DOI
  • SUZUKI Takehiro
    Center for Health and Environmental Risk Research, National Institute for Environmental Studies
  • NOHARA Keiko
    Center for Health and Environmental Risk Research, National Institute for Environmental Studies

Bibliographic Information

Other Title
  • 妊娠期ヒ素曝露したマウス精巣におけるエピジェネティック及び精子形成に関連する遺伝子発現の変化

Description

<p>In this study, to elucidate the effects of gestational arsenic exposure on the F1 reproductive system, we examined gene expression of epigenetic-related genes and spermatogenesis-related gene in F1 male mice gestationally exposed to arsenic. We found that gestational arsenic exposure probably induced DNA hypermethylation in the testis of F1 mice. Our results suggested that altered DNA methylation affected spermatogenesis through disruption of spermatogonia differentiation in the testis of gestationally arsenic exposed F1 mice.</p>

Journal

Details 詳細情報について

  • CRID
    1390848647544999424
  • NII Article ID
    130007898337
  • DOI
    10.14869/toxpt.47.1.0_p-212
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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