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Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-depolymerizing Natural Product

  • Ohyoshi Takayuki
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
  • Kigoshi Hideo
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba

Abstract

<p>Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons, actin and tubulin. This review discusses recent progress in the design of artificial analogs including hybridization and structure-activity relationship studies of aplyronine A.</p>

Journal

  • Chemistry Letters

    Chemistry Letters 50 (4), 580-584, 2021-04-05

    The Chemical Society of Japan

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