{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390851264574674048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11477/mf.1436204419"}},{"identifier":{"@type":"PMID","@value":"34092552"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"ja","@value":"特集 グリオーマ-現在の常識と近未来のスタンダード Ⅰ知っておくべきグリオーマの生物学的基礎知識 グリオーマの細胞生物学"},{"@value":"[Glioma Cell Biology]."}],"description":[{"notation":[{"@value":"In this review, I summarized the biology of gliomas. Through past clinical and basic studies, I reviewed the evidence of the cell of origin of gliomas and the presence of brain tumor-initiating cells in gliomas, which are driven by multiple genomic alterations. In addition, the complicated tumor heterogeneity and neuronal-glioma network were studied. These mechanisms may underlie the treatment resistance and poor prognosis and support the identification of novel therapeutic targets for gliomas."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326216203648","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00512055"},{"@type":"NRID","@value":"1000000512055"},{"@type":"NRID","@value":"9000412162606"},{"@type":"NRID","@value":"9000382049388"},{"@type":"NRID","@value":"9000415317964"},{"@type":"NRID","@value":"9000409610720"},{"@type":"NRID","@value":"9000412162612"},{"@type":"NRID","@value":"9000414804662"},{"@type":"NRID","@value":"9000412368203"},{"@type":"NRID","@value":"9000404318764"},{"@type":"NRID","@value":"9000408585857"},{"@type":"NRID","@value":"9000402298607"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000017254"}],"foaf:name":[{"@value":"立石 健祐"}],"jpcoar:affiliationName":[{"@value":"横浜市立大学大学院医学研究科脳神経外科学"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03012603"},{"@type":"EISSN","@value":"18821251"}],"prism:publicationName":[{"@language":"ja","@value":"Neurological Surgery 脳神経外科"}],"dc:publisher":[{"@language":"ja","@value":"株式会社医学書院"}],"prism:publicationDate":"2021-05-10","prism:volume":"49","prism:number":"3","prism:startingPage":"476","prism:endingPage":"484"},"reviewed":"true","availableAt":"2021-05-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Neoplasms","dc:title":"Brain Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Glioma","dc:title":"Glioma"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256996483200","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K09488"},{"@type":"JGN","@value":"JP19K09488"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09488/"}],"notation":[{"@language":"ja","@value":"IDH変異神経膠腫のDNA高変異に起因する悪性化回避を目指した治療法の開発"},{"@language":"en","@value":"Therapeutic strategy for IDH mutant gliomas with DNA hypermutation phenotype"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2008488321"},{"@type":"KAKEN","@value":"PRODUCT-23692860"},{"@type":"OPENAIRE","@value":"pmid_dedup__::ee6a55a4777a4cf2deb7d8c7f121ff0c"}]}