{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390851862123647488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.7879/siej.24.125"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"031640708"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/031640708"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I031640708"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/siej/24/2/24_125/_pdf"}},{"identifier":{"@type":"NAID","@value":"130008070705"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2021349127"}}],"dc:title":[{"@language":"en","@value":"Chemicals in aerosols generated from heated tobacco products and their biological effects"},{"@language":"ja","@value":"加熱式たばこ主流煙の化学分析と生体影響評価"},{"@language":"ja-Kana","@value":"カネツシキ タバコ シュリュウ エン ノ カガク ブンセキ ト セイタイ エイキョウ ヒョウカ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"In response to the growing health consciousness of smokers and the amended Health Promotion Law, which was fully enforced in April 2020, the number of users of heated tobacco products (HTPs) is increasing. Along with market expansion, competition for the development of HTPs has intensified, and the types of heating devices and their tobacco sticks have been increasing every year. HTPs reduce the amount of chemicals in mainstream smoke, but there is little evidence for health risks to active and passive smokers. The ISO (International Organization for Standardization) method and the HCI (Health Canada Intense) method are used as standard methods for chemical analysis of mainstream smoke generated from combustion cigarettes. For HTPs, CORESTA (the Cooperation Center for Scientific Research Relative to Tobacco) has published the technical report (Heated Tobacco Product-259-CORESTA technical report) for the collection of mainstream smoke in July 2020. This review outlines the characteristics and types of HTPs, puffing protocols for chemical analysis, and the biological effects of mainstream smoke generated from HTPs."},{"@language":"ja","@value":"喫煙者の健康志向の高まりや2020年4月から完全施行された改正健康増進法を受けて，紙巻きたばこの喫煙から加熱式たばこ製品の使用へと，喫煙者の行動変容が進んでいる。それに伴い，加熱式たばこ製品の開発競争も激しさを増し，加熱式たばこの加熱装置や専用たばこスティックの種類は，年々増加の一途をたどっている。加熱式たばこでは，主流煙中の化学物質量が低減されているが，能動喫煙者や受動喫煙者の健康リスクに関する科学的エビデンスは圧倒的に少ない。また，たばこ主流煙の吸煙プロトコールとして，紙巻きたばこの場合，ISO(International Organization for Standardization)法やHCI(Health Canada Intense)法が標準的な方法として用いられているが，加熱式たばこでは，CORESTA(the Cooperation Centre for Scientific Research Relative to Tobacco)の技術報告書(Heated Tobacco Product-259-CORESTA technical report)が2020年7月に公表されたばかりで，世界標準の方法は確立されていない。本総説では，加熱式たばこ製品の特徴や種類，化学分析のための吸煙条件，加熱式たばこ主流煙の生体影響について，概説する。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326218094592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20307771"},{"@type":"NRID","@value":"1000020307771"},{"@type":"NRID","@value":"9000004518124"},{"@type":"NRID","@value":"9000004118303"},{"@type":"NRID","@value":"9000270140842"},{"@type":"NRID","@value":"9000000709340"},{"@type":"NRID","@value":"9000324995814"},{"@type":"NRID","@value":"9000413254615"},{"@type":"NRID","@value":"9000018827395"},{"@type":"NRID","@value":"9000280546907"},{"@type":"NRID","@value":"9000021178006"},{"@type":"NRID","@value":"9000402582591"},{"@type":"NRID","@value":"9000004534675"},{"@type":"NRID","@value":"9000340953500"},{"@type":"NRID","@value":"9000021294737"},{"@type":"NRID","@value":"9000004534805"},{"@type":"NRID","@value":"9000242073683"},{"@type":"NRID","@value":"9000410628662"},{"@type":"NRID","@value":"9000000586240"},{"@type":"NRID","@value":"9000370759065"},{"@type":"NRID","@value":"9000021257316"},{"@type":"NRID","@value":"9000004534626"},{"@type":"NRID","@value":"9000324995816"},{"@type":"NRID","@value":"9000346963448"},{"@type":"NRID","@value":"9000248215894"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takahiro_horinouchi"}],"foaf:name":[{"@language":"en","@value":"HORINOUCHI Takahiro"},{"@language":"ja","@value":"堀之内 孝広"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北海道大学　大学院医学研究院　細胞薬理学教室"},{"@language":"en","@value":"Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851862123647491","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413254616"}],"foaf:name":[{"@language":"en","@value":"NIO-KOBAYASHI Junko"},{"@language":"ja","@value":"小林 純子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北海道大学　大学院医学研究院　組織細胞学教室"},{"@language":"en","@value":"Laboratory of Histology and Cytology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326228489728","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10463829"},{"@type":"NRID","@value":"1000010463829"},{"@type":"NRID","@value":"9000410269104"},{"@type":"NRID","@value":"9000290380692"},{"@type":"NRID","@value":"9000324995791"},{"@type":"NRID","@value":"9000410269099"},{"@type":"NRID","@value":"9000362197789"},{"@type":"NRID","@value":"9000413254617"},{"@type":"NRID","@value":"9000413372380"},{"@type":"NRID","@value":"9000253184039"},{"@type":"NRID","@value":"9000402071896"},{"@type":"NRID","@value":"9000402071991"},{"@type":"NRID","@value":"9000413372354"},{"@type":"NRID","@value":"9000322100978"},{"@type":"NRID","@value":"9000413254043"},{"@type":"NRID","@value":"9000402400304"},{"@type":"NRID","@value":"9000391935846"},{"@type":"NRID","@value":"9000402263934"},{"@type":"NRID","@value":"9000405652624"},{"@type":"NRID","@value":"9000286635875"},{"@type":"NRID","@value":"9000403423095"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0104259"}],"foaf:name":[{"@language":"en","@value":"HIGASHI Kyohei"},{"@language":"ja","@value":"東 恭平"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東京理科大学　薬学部　薬学科　病態分析化学研究室"},{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Tokyo University of Science"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851862123647488","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413254618"}],"foaf:name":[{"@language":"en","@value":"MIWA Soichi"},{"@language":"ja","@value":"三輪 聡一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"公立豊岡病院"},{"@language":"en","@value":"Toyooka General Hospital"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18820395"},{"@type":"EISSN","@value":"21864322"},{"@type":"NDL_BIB_ID","@value":"000008510751"},{"@type":"ISSN","@value":"18820395"},{"@type":"LISSN","@value":"18820395"},{"@type":"NCID","@value":"AA11443020"}],"prism:publicationName":[{"@language":"en","@value":"Indoor Environment"},{"@language":"ja","@value":"室内環境"},{"@language":"ja","@value":"室内環境"},{"@language":"en","@value":"Indoor Environment"}],"dc:publisher":[{"@language":"en","@value":"Society of Indoor Environment, Japan"},{"@language":"ja","@value":"一般社団法人 室内環境学会"}],"prism:publicationDate":"2021","prism:volume":"24","prism:number":"2","prism:startingPage":"125","prism:endingPage":"133"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/031640708"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031640708"},{"@id":"https://www.jstage.jst.go.jp/article/siej/24/2/24_125/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2021349127"}],"availableAt":"2021","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%8A%A0%E7%86%B1%E5%BC%8F%E3%81%9F%E3%81%B0%E3%81%93","dc:title":"加熱式たばこ"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%81%9F%E3%81%B0%E3%81%93%E4%B8%BB%E6%B5%81%E7%85%99%E6%B0%B4%E6%8A%BD%E5%87%BA%E7%89%A9","dc:title":"たばこ主流煙水抽出物"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%90%B8%E7%85%99%E3%83%97%E3%83%AD%E3%83%88%E3%82%B3%E3%83%BC%E3%83%AB","dc:title":"吸煙プロトコール"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AB%E3%83%AB%E3%83%9C%E3%83%8B%E3%83%AB%E5%8C%96%E5%90%88%E7%89%A9","dc:title":"カルボニル化合物"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%82%AF%E3%83%AD%E3%83%AC%E3%82%A4%E3%83%B3","dc:title":"アクロレイン"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A1%80%E7%AE%A1%E5%86%85%E7%9A%AE%E9%9A%9C%E5%AE%B3","dc:title":"血管内皮障害"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%85%B8%E5%8C%96%E3%82%B9%E3%83%88%E3%83%AC%E3%82%B9","dc:title":"酸化ストレス"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%81%9F%E3%81%B0%E3%81%93%E3%83%8F%E3%83%BC%E3%83%A0%E3%83%AA%E3%83%80%E3%82%AF%E3%82%B7%E3%83%A7%E3%83%B3","dc:title":"たばこハームリダクション"},{"@id":"https://cir.nii.ac.jp/all?q=heated%20tobacco%20product","dc:title":"heated tobacco product"},{"@id":"https://cir.nii.ac.jp/all?q=cigarette%20smoke%20extract","dc:title":"cigarette smoke extract"},{"@id":"https://cir.nii.ac.jp/all?q=puffing%20protocol","dc:title":"puffing protocol"},{"@id":"https://cir.nii.ac.jp/all?q=carbonyl%20compounds","dc:title":"carbonyl compounds"},{"@id":"https://cir.nii.ac.jp/all?q=acrolein","dc:title":"acrolein"},{"@id":"https://cir.nii.ac.jp/all?q=endothelial%20dysfunction","dc:title":"endothelial dysfunction"},{"@id":"https://cir.nii.ac.jp/all?q=oxidative%20stress","dc:title":"oxidative stress"},{"@id":"https://cir.nii.ac.jp/all?q=tobacco%20harm%20reduction","dc:title":"tobacco harm reduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232532492800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144649032192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quitting Smoking Among Adults — United States, 2000–2015"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095153247616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571401011072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nicotine replacement therapy versus control for smoking cessation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043643645824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Geburtstage/Verstorben"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044474422272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994255184896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cigarette filter ventilation is a defective design because of misleading taste, bigger puffs, and blocked vents"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418639983616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Simple Determination of Gaseous and Particulate Compounds Generated from Heated Tobacco Products"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419731925504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acetaldehyde in Mainstream Tobacco Smoke:  Formation and Occurrence in Smoke and Bioavailability in the Smoker"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419941463296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Determination of nicotine, tar, volatile organic compounds and carbonyls in mainstream cigarette smoke using a glass filter and a sorbent cartridge followed by the two-phase/one-pot elution method with carbon disulfide and methanol"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318946270080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Heated Tobacco Products: Volatile Emissions and Their Predicted Impact on Indoor Air Quality"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796209837440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nicotine Addiction"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269466465152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205178705280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nicotine- and Tar-Free Cigarette Smoke Induces Cell Damage Through Reactive Oxygen Species Newly Generated by PKC-Dependent Activation of NADPH Oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1390004951538089088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609939584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Carbonyl Compounds in the Gas Phase of Cigarette Mainstream Smoke and Their Pharmacological Properties"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2008709730"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I031640708"},{"@type":"CROSSREF","@value":"10.7879/siej.24.125"},{"@type":"CIA","@value":"130008070705"},{"@type":"OPENAIRE","@value":"doi_dedup___::40972bbad289a451ff6d73e3a2e727bf"}]}