{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390853200320173568.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1292/jvms.21-0495"}},{"identifier":{"@type":"PMID","@value":"34670921"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jvms/83/12/83_21-0495/_pdf"}},{"identifier":{"@type":"NAID","@value":"130008124209"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2023054317"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Estrogen modulates the skeletal muscle regeneration process and myotube morphogenesis: morphological analysis in mice with a low estrogen status"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>The purpose of this study was to elucidate the functions of estrogen and two estrogen receptors (ERs; ERα and ERβ) in the myoregeneration process and morphogenesis. Cardiotoxin (CTX) was injected into the tibialis anterior (TA) muscles of ovariectomized (OVX) mice to induce muscle injury, and subsequent myoregeneration was morphologically assessed. The diameter of regenerated myotubes in OVX mice was significantly smaller than that in intact mice at all time points of measurement. OVX mice also showed lower muscle recovery rates and slower speeds than did intact mice. ER protein levels showed a predominance of ERβ over ERα in both intact and OVX states. The ERβ level was increased significantly at 7 days after CTX injection in OVX mice and remained at a high level until 14 days. In addition, continuous administration of E2 to OVX mice in which muscle injury was induced resulted in a significantly larger diameter of regenerated myotubes than that in mice that did not receive estrogen. The results indicate that estrogen is an essential factor in the myoregeneration process since estrogen depletion delayed myoregeneration in injured muscles and administration of estrogen under the condition of a low estrogen status rescued delayed myoregeneration. The results strongly suggested that ERβ may be a factor that promotes myoregeneration more than does ERα.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410853200320173570","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414519776"}],"foaf:name":[{"@language":"en","@value":"CHAIYASING Rattanatrai"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan"},{"@language":"en","@value":"Faculty of Veterinary Sciences, Maha Sarakham University, Maha Sarakham 44000, Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853200320173568","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414519777"}],"foaf:name":[{"@language":"en","@value":"SUGIURA Akihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853200320173573","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414519778"}],"foaf:name":[{"@language":"en","@value":"ISHIKAWA Takuro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853200320173571","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414519779"}],"foaf:name":[{"@language":"en","@value":"OJIMA Koichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Muscle Biology Research Unit, Division of Animal Products Research, Institute of Livestock and Grassland Science, NARO, 2 Ikenodai, Tsukuba, Ibaraki 305-0901, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801208477184","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40452669"},{"@type":"NRID","@value":"1000040452669"},{"@type":"NRID","@value":"9000258010671"},{"@type":"NRID","@value":"9000415346604"},{"@type":"NRID","@value":"9000006187017"},{"@type":"NRID","@value":"9000398787368"},{"@type":"NRID","@value":"9000406324803"},{"@type":"NRID","@value":"9000017306969"},{"@type":"NRID","@value":"9000021953638"},{"@type":"NRID","@value":"9000002037294"},{"@type":"NRID","@value":"9000021183155"},{"@type":"NRID","@value":"9000402266627"},{"@type":"NRID","@value":"9000020623749"},{"@type":"NRID","@value":"9000412550289"},{"@type":"NRID","@value":"9000256911357"},{"@type":"NRID","@value":"9000020930296"},{"@type":"NRID","@value":"9000020973021"},{"@type":"NRID","@value":"9000414924946"},{"@type":"NRID","@value":"9000414519780"},{"@type":"NRID","@value":"9000261022256"},{"@type":"NRID","@value":"9000411090077"},{"@type":"NRID","@value":"9000258010685"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0132561"}],"foaf:name":[{"@language":"en","@value":"WARITA Katsuhiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan"},{"@language":"en","@value":"Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853200320173572","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000414519781"}],"foaf:name":[{"@language":"en","@value":"HOSAKA Yoshinao Z."}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan"},{"@language":"en","@value":"Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09167250"},{"@type":"LISSN","@value":"09167250"},{"@type":"EISSN","@value":"13477439"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Veterinary Medical Science"},{"@language":"ja","@value":"Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ"},{"@language":"en","@value":"J. Vet. Med. Sci."},{"@language":"en","@value":"The Journal of Veterinary Medical Science"},{"@language":"ja","@value":"Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ"}],"dc:publisher":[{"@language":"en","@value":"JAPANESE SOCIETY OF VETERINARY SCIENCE"},{"@language":"ja","@value":"公益社団法人 日本獣医学会"}],"prism:publicationDate":"2021","prism:volume":"83","prism:number":"12","prism:startingPage":"1812","prism:endingPage":"1819"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/jvms/83/12/83_21-0495/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2023054317"}],"availableAt":"2021","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=cardiotoxin%20injection","dc:title":"cardiotoxin injection"},{"@id":"https://cir.nii.ac.jp/all?q=estrogen","dc:title":"estrogen"},{"@id":"https://cir.nii.ac.jp/all?q=myoregeneration","dc:title":"myoregeneration"},{"@id":"https://cir.nii.ac.jp/all?q=ovariectomized%20mice","dc:title":"ovariectomized 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