Drug Design Based on the Correlation between Functional Porphyrin Positions and Accumulation in Cancer Cells

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  • TOJO Toshifumi
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
  • KONDO Takeshi
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
  • YUASA Makoto
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science

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  • ポルフィリン官能基修飾位置に着目したドラッグデザイン
  • ポルフィリン カンノウキ シュウショク イチ ニ チャクモク シタ ドラッグデザイン

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<p>Porphyrin derivatives accumulate selectively in cancer cells and can be used as tumor imaging agent and anti-cancer drug. On the other hand, the effect of the functional porphyrin positions (β-, meso-position) on tumor accumulation has not been investigated. In this work, we investigated the effects of functional positions (β, meso-position) on porphyrins accumulation in cancer cells. We found that the accumulation of the porphyrin derivatives significantly depended on the functional porphyrins position.</p>

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