{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390855035370803968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5631/jibirinsuppl.158.1"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"031985304"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/031985304"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I031985304"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jibirinsuppl/158/0/158_1/_pdf"}},{"identifier":{"@type":"NAID","@value":"40022823875"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2022109245"}}],"dc:title":[{"@language":"en","@value":"Molecular Mechanisms of Transcriptional Upregulation of the Histamine H<sub>1</sub> Receptor Gene in the Development of Allergic Rhinitis"},{"@language":"ja","@value":"アレルギー性鼻炎におけるヒスタミンH<sub>1</sub>受容体遺伝子発現亢進の分子機構とその制御"},{"@value":"アレルギー性鼻炎におけるヒスタミンH₁受容体遺伝子発現亢進の分子機構とその制御"},{"@language":"ja-Kana","@value":"アレルギーセイ ビエン ニ オケル ヒスタミン H ₁ ジュヨウタイ イデンシ ハツゲン コウシン ノ ブンシ キコウ ト ソノ セイギョ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Histamine is a major chemical mediator involved in the development of allergic rhinitis, inducing the symptoms of allergic rhinitis through binding to the histamine H<sub>1</sub> receptor (H1R). H1R is a rate-limiting molecule in histamine signaling, with the signaling increased with elevated receptor expression levels. We found that histamine-mediated stimulation of H1R induced upregulation of the <i>H1R</i> gene through protein kinase Cδ (PKCδ) activation, and that the elevated receptor expression levels in the nasal mucosa increased histamine signaling to further exacerbate the symptoms of allergic rhinitis. Antihistamines have three effects: they block histamine signaling mediated by H1R; they suppress histamine-induced upregulation of transcriptional activation of <i>H1R</i>; they suppress basal transcription of <i>H1R</i> even in the absence of histamine. The third effect may be a part of the inverse agonist action of antihistamines. Dexamethasone inhibits both basal transcription and transcriptional activation of <i>H1R</i> through suppression of extracellular signal-regulated kinase phosphorylation. We also found that pre-seasonal prophylactic treatment with antihistamines or intranasal corticosteroid sprays suppressed the gene expression of <i>H1R</i> in the nasal mucosa, resulting in the suppression of nasal symptoms in patients with cedar pollen pollinosis. Because <i>H1R</i> is an allergic rhinitis disease-sensitive gene, a new treatment strategy for allergic rhinitis targeting PKCδ has been suggested.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751163973888","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60380028"},{"@type":"NRID","@value":"1000060380028"},{"@type":"NRID","@value":"9000003770100"},{"@type":"NRID","@value":"9000410657714"},{"@type":"NRID","@value":"9000257948549"},{"@type":"NRID","@value":"9000020926445"},{"@type":"NRID","@value":"9000311063117"},{"@type":"NRID","@value":"9000283281486"},{"@type":"NRID","@value":"9000258225930"},{"@type":"NRID","@value":"9000311063242"},{"@type":"NRID","@value":"9000413900873"},{"@type":"NRID","@value":"9000283104863"},{"@type":"NRID","@value":"9000261039186"},{"@type":"NRID","@value":"9000404787283"},{"@type":"NRID","@value":"9000399542436"},{"@type":"NRID","@value":"9000292183068"},{"@type":"NRID","@value":"9000283315201"},{"@type":"NRID","@value":"9000021554244"},{"@type":"NRID","@value":"9000243896246"},{"@type":"NRID","@value":"9000398302593"},{"@type":"NRID","@value":"9000412185508"},{"@type":"NRID","@value":"9000329015030"},{"@type":"NRID","@value":"9000412234239"},{"@type":"NRID","@value":"9000399773423"},{"@type":"NRID","@value":"9000410657715"},{"@type":"NRID","@value":"9000415417406"},{"@type":"NRID","@value":"9000370764773"},{"@type":"NRID","@value":"9000408919303"},{"@type":"NRID","@value":"9000257947990"},{"@type":"NRID","@value":"9000399773415"},{"@type":"NRID","@value":"9000292185287"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ykitamura1212"}],"foaf:name":[{"@language":"en","@value":"Kitamura 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Noriaki"},{"@language":"ja","@value":"武田 憲昭"}],"jpcoar:affiliationName":[{"@language":"en","@value":"University of Tokushima"},{"@language":"ja","@value":"徳島大学耳鼻咽喉科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09121870"},{"@type":"EISSN","@value":"21851557"},{"@type":"NDL_BIB_ID","@value":"000000043681"},{"@type":"ISSN","@value":"09121870"},{"@type":"LISSN","@value":"09121870"},{"@type":"NCID","@value":"AN10020883"}],"prism:publicationName":[{"@language":"en","@value":"Practica oto-rhino-laryngologica. Suppl."},{"@language":"ja","@value":"耳鼻咽喉科臨床　補冊"},{"@language":"en","@value":"Pract.Otol.(Kyoto)"},{"@language":"en","@value":"Jibi inkoka rinsho"},{"@language":"ja","@value":"耳鼻臨床"}],"dc:publisher":[{"@language":"en","@value":"The Society of Practical Otolaryngology"},{"@language":"ja","@value":"耳鼻咽喉科臨床学会"}],"prism:publicationDate":"2022","prism:volume":"158","prism:number":"0","prism:startingPage":"1","prism:endingPage":"11"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/031985304"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031985304"},{"@id":"https://www.jstage.jst.go.jp/article/jibirinsuppl/158/0/158_1/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2022109245"}],"availableAt":"2022","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=allergic%20rhinitis","dc:title":"allergic rhinitis"},{"@id":"https://cir.nii.ac.jp/all?q=histamine%20H%3Csub%3E1%3C/sub%3E%20receptor","dc:title":"histamine H<sub>1</sub> receptor"},{"@id":"https://cir.nii.ac.jp/all?q=antihistamine","dc:title":"antihistamine"},{"@id":"https://cir.nii.ac.jp/all?q=corticosteroid","dc:title":"corticosteroid"},{"@id":"https://cir.nii.ac.jp/all?q=protein%20kinase%20C%CE%B4","dc:title":"protein kinase Cδ"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143735680768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histamine H<sub>1</sub>-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gα<sub>q/11</sub>-Subunits in Constitutive and Agonist-Mediated Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712383165312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preseasonal prophylactic treatment with antihistamines suppresses\nnasal symptoms and expression of histamine H1 receptor mRNA in the\nnasal mucosa of patients with pollinosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618594215296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional up‐regulation of histamine receptor‐1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094986721536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased expression of histamine H<sub>1</sub> receptor mRNA in allergic rhinitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095155303424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Glucocorticoid on Upregulation of Histamine H<sub>1</sub>Receptor mRNA in Nasal Mucosa of Rats Sensitized by Exposure to Toluene Diisocyanate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096048191232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of standard medication on quality of life of 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diisocyanate (TDI) increases preprotachykinin A (PPTA) and preproCGRP mRNAs in guinea pig trigeminal ganglion neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471100869120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893503413760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845838926592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usefulness of HeLa cells to evaluate 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Agonist Activity of Bilastine"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268163531776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268905546752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histamine-induced calcium mobilization in single cultured cells expressing histamine H1 receptors: a relationship between its sensitivity and the density of H1 receptors."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270984245888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Minimal persistent inflammation in allergic rhinitis: implications for current treatment strategies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272547840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Molecular Mechanism of Up-regulation of Histamine H<sub>1</sub> Receptor mRNA in the Nasal Mucosa of Patients with Allergic Rhinitis and the Effect of Antihistamine on Histamine H<sub>1</sub> Receptor Expression"},{"@language":"ja","@value":"アレルギー性鼻炎におけるヒスタミンH<sub>1</sub>受容体遺伝子発現亢進の分子機構とその制御"},{"@value":"アレルギー性鼻炎におけるヒスタミンH₁受容体遺伝子発現亢進の分子機構とその制御"},{"@language":"ja-Kana","@value":"アレルギーセイ ビエン ニ オケル ヒスタミン H ₁ ジュヨウタイ イデンシ ハツゲン コウシン ノ ブンシ キコウ ト ソノ セイギョ"},{"@value":"The Molecular Mechanism of Up-regulation of Histamine H1 Receptor mRNA in the Nasal Mucosa of Patients with Allergic Rhinitis and the Effect of Antihistamine on Histamine H1 Receptor Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205181477632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1390003825199999104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Japanese guidelines for allergic rhinitis 2020"},{"@value":"Japanese Society of Allergology. Japanese guidelines for allergic rhinitis 2020"},{"@value":"Japanese Society of A: Japanese guidelines for allergic rhinitis 2020"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680154256384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stimulation of Histamine H1 Receptor Up-Regulates Histamine H1 Receptor Itself Through Activation of Receptor Gene Transcription"},{"@value":"Stimulation of histamine H1 receptor up-regulates histamine receptor itself through activation of receptor gene transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680156847232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate-Sensitized Rats"},{"@value":"Repeated pre-treatment with antihistamines suppresses transcriptional up-regulations of histamine H1 receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats"},{"@value":"Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390567901489842304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2009335324"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I031985304"},{"@type":"CROSSREF","@value":"10.5631/jibirinsuppl.158.1"},{"@type":"CIA","@value":"40022823875"},{"@type":"OPENAIRE","@value":"doi_________::c178fd3902329a118034f214b9595265"}]}