{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390863629154671488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5106/jjshns.34.99"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jjshns/34/1/34_34.99/_pdf"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2024297457"}}],"dc:title":[{"@language":"en","@value":"A case of Marine-Lenhart Syndrome （MLS）"},{"@language":"ja","@value":"Marine-Lenhart症候群（MLS）の1例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Marine-Lenhart syndrome consists of coexisting Basedow’s and Plummer’s diseases.  Here, we report a case of Marine-Lenhart syndrome, in which hyperthyroidism was detected during the follow-up of a thyroid tumor, and the diagnosis was made based on scintigraphy findings.\n<br>A 69-year-old woman had been diagnosed with a left thyroid tumor more than 20 years ago.  Because cytological examination suggested a benign tumor, surgical removal was not performed.  She was diagnosed with hyperthyroidism by a local family doctor, and was referred to our department for further examination.  TRAb was positive, and CT and echography showed a substantial mass with a maximum diameter of 32 mm in the left lobe of the thyroid gland.  I<sup>123</sup> scintigraphy showed an accumulation in the left lobe tumor, and weak but diffuse accumulation in other lesions of the thyroid glands.  Based on these findings, she was diagnosed with Marine-Lenhart syndrome.  The patient was treated with total thyroidectomy, and no malignant findings were observed."},{"@language":"ja","@value":"【はじめに】Marine-Lenhart症候群は，Basedow病とPlummer病の2つの異なる病態が併存する疾患である。今回われわれは，甲状腺腫瘍の経過観察中に甲状腺機能亢進症を指摘され，各画像所見からMarine-Lenhart症候群の診断となった1例を経験したので，若干の文献的考察を加えて報告する。\n<br>【症例】69歳女性。20年以上前に左甲状腺腫瘍の指摘があったが，細胞診で良性の結果で経過観察となっていた。健康診断で甲状腺機能亢進を指摘され，近医耳鼻咽喉科を受診。エコーで左葉に結節を認め，free T3およびfree T4が高値だったため，Plummer病の疑いで精査加療目的に当科紹介初診となった。当院での採血でTRAbが陽性であり，CTやエコーでは甲状腺左葉に最大径32mmの充実性腫瘤を認めた。同腫瘤の穿刺吸引細胞診では悪性所見は認めなかった。I<sup>123</sup>シンチグラフィーでは甲状腺左葉腫瘍に集積を認め，それ以外の甲状腺実質にも淡い集積を認めた。以上からMarine-Lenhart症候群と診断し，甲状腺全摘術を施行した。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410863629154671492","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"熊井 琢美"},{"@language":"en","@value":"Kumai Takumi"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"},{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"},{"@language":"en","@value":"Department of Innovative Head & Neck Cancer Research and Treatment（IHNCRT）, Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学頭頸部癌先端的診断・治療学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410863629154671488","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Miyakoshi Kaoru"},{"@language":"ja","@value":"宮越 薫"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北見赤十字病院頭頸部・耳鼻咽喉科"},{"@language":"en","@value":"Japanese Red Cross Kitami Hospital"},{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410863629154671493","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"大原 賢三"},{"@language":"en","@value":"Ohara Kenzo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410863629154671491","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"岸部 幹"},{"@language":"en","@value":"Kishibe Kan"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"},{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410863629154671490","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Takahara Miki"},{"@language":"ja","@value":"高原 幹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"},{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"},{"@language":"en","@value":"Department of Innovative Head & Neck Cancer Research and Treatment（IHNCRT）, Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学頭頸部癌先端的診断・治療学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410863629154671489","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hayashi Tatsuya"},{"@language":"ja","@value":"林 達哉"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"旭川医科大学耳鼻咽喉科・頭頸部外科学講座"},{"@language":"en","@value":"Department of Otolaryngology-Head and Neack Surgery, Asahikawa Medical University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1349581X"},{"@type":"EISSN","@value":"1884474X"}],"prism:publicationName":[{"@language":"en","@value":"JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY"},{"@language":"ja","@value":"頭頸部外科"},{"@language":"en","@value":"J Jpn Soc Head Neck Surg"},{"@language":"en","@value":"Toukeibu geka"},{"@language":"ja","@value":"頭頸部外科"},{"@language":"en","@value":"J J pn Soc Head Neck Surg"}],"dc:publisher":[{"@language":"en","@value":"JAPAN SOCIETY FOR HEAD AND NECK SURGERY"},{"@language":"ja","@value":"特定非営利活動法人 日本頭頸部外科学会"}],"prism:publicationDate":"2024","prism:volume":"34","prism:number":"1","prism:startingPage":"99","prism:endingPage":"103"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/jjshns/34/1/34_34.99/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2024297457"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Marine-Lenhart%E7%97%87%E5%80%99%E7%BE%A4","dc:title":"Marine-Lenhart症候群"},{"@id":"https://cir.nii.ac.jp/all?q=Plummer%E7%97%85","dc:title":"Plummer病"},{"@id":"https://cir.nii.ac.jp/all?q=Basedow%E7%97%85","dc:title":"Basedow病"},{"@id":"https://cir.nii.ac.jp/all?q=I%3Csup%3E123%3C/sup%3E%E3%82%B7%E3%83%B3%E3%83%81%E3%82%B0%E3%83%A9%E3%83%95%E3%82%A3%E3%83%BC","dc:title":"I<sup>123</sup>シンチグラフィー"},{"@id":"https://cir.nii.ac.jp/all?q=Marine-Lenhart%20syndrome","dc:title":"Marine-Lenhart syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Plummer%20disease","dc:title":"Plummer disease"},{"@id":"https://cir.nii.ac.jp/all?q=Basedow%20disease","dc:title":"Basedow disease"},{"@id":"https://cir.nii.ac.jp/all?q=I%3Csup%3E123%3C/sup%3E%20scintigraphy","dc:title":"I<sup>123</sup> scintigraphy"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360864115481274880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence and Treatment Outcomes of Marine-Lenhart Syndrome in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204852112000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"硝子化索状腫瘍によるMarine-Lenhart症候群の1例"},{"@language":"en","@value":"A Case of Marine-Lenhart Syndrome with a Hyalinizing Trabecular Tumor Located in an Autonomous Hyperfunctioning Thyroid Nodule"},{"@value":"症例 硝子化索状腫瘍によるMarine-Lenhart症候群の1例"},{"@language":"ja-Kana","@value":"ショウレイ ガラスカサクジョウ シュヨウ ニ ヨル Marine-Lenhart ショウコウグン ノ 1レイ"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013243748"},{"@type":"CROSSREF","@value":"10.5106/jjshns.34.99"},{"@type":"OPENAIRE","@value":"doi_________::976f8ba6bf02329ce5a9d46f315f7d6c"}]}