- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Immobilization of Enzymes Using Water-Soluble Metal-Organic Polyhedra
-
- LE OUAY Benjamin
- Kyushu University
-
- OHBA Masaaki
- Kyushu University
Search this article
Description
<p>Immobilization of enzymes is a potent strategy to improve their applicability for industrial or technological applications. This highlight describes our strategy of developing a family of cage-like compounds called metal-organic polyhedra (MOPs) functionalized to have a high solubility in water, in order to form self-assembled structures with enzymes. The high affinity of the developed MOPs for the surface of proteins enabled an easy yet versatile “Mix-and-shake” method to form aggregates in which enzymes are cross-linked by robust microporous units. Furthermore, the physical state of the MOP-enzymes composites, from colloids to solid precipitates, can easily be controlled by adjusting the mixing MOP-to-protein ratio. Immobilized enzymes maintained a high catalytic activity in the solid-state, and also showed a good recyclability and an improved stability. Furthermore, the unique nature of MOPs as well-defined yet highly tunable nanosized molecular entities can be used to mimic microscale environments in complex systems, and modify proteins’ configuration and activity in well-controlled conditions.</p>
Journal
-
- POLYMERS
-
POLYMERS 74 (1), 15-17, 2025
The Society of Polymer Science, Japan