{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390866040578167936.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5059/yukigoseikyokaishi.83.153"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/83/2/83_153/_pdf"}}],"dc:title":[{"@language":"en","@value":"Efficient synthesis of Azabicyclo[3.1.1]heptanes via Strain-release Cycloadditions of Bicyclo[1.1.0]butanes"},{"@language":"ja","@value":"ビシクロブタン骨格の開裂を起点とする高効率アザビシクロ[3.1.1]ヘプタン合成"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Azabicyclo[3.1.1]heptanes are recognized as bioisosteres of the meta-substituted pyridine scaffold, as their bridgehead substitution mimics the arrangement of substituents on the meta-substituted pyridine. However, the synthesis of azabicyclo[3.1.1]heptanes remains underdeveloped. This mini-review highlights recent advances in their synthesis through strain-release cycloadditions of bicyclo[1.1.0]butanes.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410866040578167936","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Tagami Takuma"},{"@language":"ja","@value":"田上 拓磨"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学大学院薬学研究院"},{"@language":"en","@value":"Graduate School of Pharmaceutical Sciences, Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00379980"},{"@type":"EISSN","@value":"18836526"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Synthetic Organic Chemistry, Japan"},{"@language":"ja","@value":"有機合成化学協会誌"},{"@language":"en","@value":"J. Synth. Org. Chem. Jpn."},{"@language":"en","@value":"yukigoseikyokaishi"},{"@language":"en","@value":"J. Synth. Org. Chem., Jpn."},{"@language":"ja","@value":"有合化"},{"@language":"en","@value":"J. Syn. Org. Chem., Jpn."}],"dc:publisher":[{"@language":"en","@value":"The Society of Synthetic Organic Chemistry, Japan"},{"@language":"ja","@value":"公益社団法人 有機合成化学協会"}],"prism:publicationDate":"2025-02-01","prism:volume":"83","prism:number":"2","prism:startingPage":"153","prism:endingPage":"154"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/83/2/83_153/_pdf"}],"availableAt":"2025-02-01","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302870460445056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bicyclobutanes: from curiosities to versatile reagents and covalent warheads"}]},{"@id":"https://cir.nii.ac.jp/crid/1360303972863672704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Silver‐Enabled Cycloaddition of Bicyclobutanes with Isocyanides for the Synthesis of Polysubstituted 3‐Azabicyclo[3.1.1]heptanes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360303976320641664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Azabicyclo[3.1.1]heptenes Enabled by Catalyst-Controlled Annulations of Bicyclo[1.1.0]butanes with Vinyl Azides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360303976491692800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High-Curie-Temperature Elastic Polymer Ferroelectric by Carbene Cross-Linking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360585447844728448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"General Synthesis of 3‐Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres**"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861295381022976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369853134080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013852104"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.83.153"}]}