{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390867111745744640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.18978/jscrp.59.1_30"}},{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/2324/7385207"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"033619711"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/033619711"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I033619711"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"ja","@value":"アレロケミカルの研究から植物根の重力屈性特異的阻害剤（BMA）の開発へ"},{"@language":"en","@value":"Development of root gravitropism inhibitors from allelochemical research"},{"@language":"ja-Kana","@value":"アレロケミカル ノ ケンキュウ カラ ショクブツ コン ノ ジュウリョク クッセイ トクイテキ ソガイザイ(BMA)ノ カイハツ エ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Allelopathy is one of the survival strategies employed by plants, and allelochemicals, which play a critical role, are expected to be useful compounds in plant physiology research tools, as well as lead compounds for pesticides and growth regulators. <i>cis</i>-Cinnamic acid, the active compound of <i>cis</i>-cinnamic acid glycosides isolated from <i>Spiraea thunbergii</i>, exhibits strong inhibitory effects on the elongation of plant roots. Our research group, consisting of plant physiologists and organic chemists, synthesized <i>cis</i>-cinnamic acid and developed a fluorescent probe through structure-activity relationship studies, revealing the root cap with high affinity for <i>cis</i>-cinnamic acid through molecular imaging experiments. Drawing inspiration from the inhibitory effect on gravitropism, we screened <i>cis</i>-cinnamic acid analogues and discovered ku-76 (2<i>Z</i>,4<i>E</i>-5-phenylpenta-2,4-dienoic acid), which specifically inhibits gravitropism. Using this as a lead compound, we further modified its structure and successfully developed BMA ((<i>Z</i>)-4-((<i>Z</i>)-<u>b</u>enzylidene)-6-(4-<u>m</u>ethoxyphenyl)hex-2-en-5-ynoic <u>a</u>cid), a potent inhibitor. Additionally, plant physiology experiments on auxin distribution suggest its involvement in the control of polar auxin transport.</p>"},{"@language":"ja","@value":"<p>Allelopathy is one of the survival strategies employed by plants, and allelochemicals, which play a critical role, are expected to be useful compounds in plant physiology research tools, as well as lead compounds for pesticides and growth regulators. <i>cis</i>-Cinnamic acid, the active compound of <i>cis</i>-cinnamic acid glycosides isolated from <i>Spiraea thunbergii</i>, exhibits strong inhibitory effects on the elongation of plant roots. Our research group, consisting of plant physiologists and organic chemists, synthesized <i>cis</i>-cinnamic acid and developed a fluorescent probe through structure-activity relationship studies, revealing the root cap with high affinity for <i>cis</i>-cinnamic acid through molecular imaging experiments. Drawing inspiration from the inhibitory effect on gravitropism, we screened <i>cis</i>-cinnamic acid analogues and discovered ku-76 (2<i>Z</i>,4<i>E</i>-5-phenylpenta-2,4-dienoic acid), which specifically inhibits gravitropism. Using this as a lead compound, we further modified its structure and successfully developed BMA ((<i>Z</i>)-4-((<i>Z</i>)-<u>b</u>enzylidene)-6-(4-<u>m</u>ethoxyphenyl)hex-2-en-5-ynoic <u>a</u>cid), a potent inhibitor. Additionally, plant physiology experiments on auxin distribution suggest its involvement in the control of polar auxin transport.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326220158592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40226345"},{"@type":"NRID","@value":"1000040226345"},{"@type":"ORCID","@value":"0000-0002-0588-8075"},{"@type":"CINII_AUTHOR_ID","@value":"DA15901700"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA15901700#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA15901700"},{"@type":"NRID","@value":"9000254242755"},{"@type":"NRID","@value":"9000255958435"},{"@type":"NRID","@value":"9000006705566"},{"@type":"NRID","@value":"9000259861025"},{"@type":"NRID","@value":"9000410606886"},{"@type":"NRID","@value":"9000362198542"},{"@type":"NRID","@value":"9000412368227"},{"@type":"NRID","@value":"9000413339583"},{"@type":"NRID","@value":"9000010671924"},{"@type":"NRID","@value":"9000261035956"},{"@type":"NRID","@value":"9000021943481"},{"@type":"NRID","@value":"9000005281306"},{"@type":"NRID","@value":"9000323300930"},{"@type":"NRID","@value":"9000415307176"},{"@type":"NRID","@value":"9000005168869"},{"@type":"NRID","@value":"9000411115035"},{"@type":"NRID","@value":"9000010103565"},{"@type":"NRID","@value":"9000412104389"},{"@type":"NRID","@value":"9000414810583"},{"@type":"NRID","@value":"9000370735751"},{"@type":"NRID","@value":"9000406228319"},{"@type":"NRID","@value":"9000415307170"},{"@type":"NRID","@value":"9000005184556"},{"@type":"NRID","@value":"9000243876935"},{"@type":"NRID","@value":"9000410738833"},{"@type":"NRID","@value":"9000404681260"},{"@type":"NRID","@value":"9000390430001"},{"@type":"NRID","@value":"9000410882921"},{"@type":"NRID","@value":"9000410041127"},{"@type":"NRID","@value":"9000242073284"},{"@type":"NRID","@value":"9000254716128"},{"@type":"NRID","@value":"9000415307165"},{"@type":"NRID","@value":"9000316695098"},{"@type":"NRID","@value":"9000005203811"},{"@type":"NRID","@value":"9000410606884"},{"@type":"NRID","@value":"9000242086850"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184913"}],"foaf:name":[{"@language":"ja","@value":"新藤 充"},{"@language":"en","@value":"Shindo Mitsuru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Institute for Materials Chemistry and Engineering, Kyushu University"},{"@language":"ja","@value":"九州大学・先導物質化学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410867111745744642","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0001-8991-9248"}],"foaf:name":[{"@language":"ja","@value":"岩田 隆幸"},{"@language":"en","@value":"Iwata Takayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Institute for Materials Chemistry and Engineering, Kyushu University"},{"@language":"ja","@value":"九州大学・先導物質化学研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198642176","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50599983"},{"@type":"NRID","@value":"1000050599983"},{"@type":"ORCID","@value":"0000-0002-1813-2832"},{"@type":"NRID","@value":"9000018798424"},{"@type":"NRID","@value":"9000413528669"},{"@type":"NRID","@value":"9000238238575"},{"@type":"NRID","@value":"9000412547449"},{"@type":"NRID","@value":"9000018277936"},{"@type":"NRID","@value":"9000397842155"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ta-nishi2466"}],"foaf:name":[{"@language":"ja","@value":"西村 岳志"},{"@language":"en","@value":"Nishimura Takeshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Plant Environmental Responses, National Institute for Basic Biology"},{"@language":"ja","@value":"自然科学研究機構・基礎生物学研究所・植物環境応答研究部門"}]},{"@id":"https://cir.nii.ac.jp/crid/1410867111745744643","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"森田（寺尾） 美代"},{"@language":"en","@value":"Terao-Morita Miyo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Plant Environmental Responses, National Institute for Basic Biology"},{"@language":"ja","@value":"自然科学研究機構・基礎生物学研究所・植物環境応答研究部門"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13465406"},{"@type":"EISSN","@value":"21896305"},{"@type":"NDL_BIB_ID","@value":"000000390676"},{"@type":"ISSN","@value":"13465406"},{"@type":"LISSN","@value":"13465406"},{"@type":"NCID","@value":"AA11550064"}],"prism:publicationName":[{"@language":"ja","@value":"植物の生長調節"},{"@language":"en","@value":"Regulation of Plant Growth & Development"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society for Chemical Regulation of Plants"},{"@language":"ja","@value":"一般社団法人 植物化学調節学会"}],"prism:publicationDate":"2024","prism:volume":"59","prism:number":"1","prism:startingPage":"30","prism:endingPage":"37"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/033619711"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I033619711"}],"availableAt":"2024","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2014047186"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01211:0006934462"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I033619711"}]}