Cytotoxicity of surface pre-reacted glass-ionomer filler containing composite resin in human periodontal ligament cells
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- MUKUNOKI Yuriko
- Department of Regenerative Dental Medicine, Tokushima University Graduate School of Biomedical Sciences
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- JIN Shengjian
- Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima University Graduate School of Biomedical Sciences Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University
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- TAMAKI Naofumi
- Department of Preventive Dentistry, Kagoshima University Graduate School of Medicine and Dental Sciences
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- KUDO Yasusei
- Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima University Graduate School of Biomedical Sciences
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- HOSAKA Keiichi
- Department of Regenerative Dental Medicine, Tokushima University Graduate School of Biomedical Sciences Institute of Post-LED Photonics, Tokushima University
書誌事項
- 公開日
- 2025-07-25
- 資源種別
- journal article
- DOI
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- 10.4012/dmj.2025-003
- 公開者
- 一般社団法人 日本歯科理工学会
この論文をさがす
説明
<p>This study evaluated the cytotoxicity of various composite resins (CRs) on human periodontal ligament (PDL) cells, focusing on material composition and ion release. Eight CRs of three sizes were tested: Large (6.5 mm diameter, 1.5 mm thickness), Medium (2.0 mm diameter, 1.5 mm thickness), and Small (1.5 mm diameter, 0.5 mm thickness). Cytotoxicity was assessed by cell counting on immortalized and primary PDL cell lines. CRs containing Surface pre-reacted glass ionomer filler showed significant size-dependent cytotoxicity, with larger specimens exhibiting higher ion release of BO33−, Sr2+, SiO32−, and F−, which correlated with adverse effects. Smaller specimens with reduced ion release had lower cytotoxicity and sometimes promoted cell proliferation. These results emphasize the role of material composition and ion release in the biocompatibility of CR for subgingival restorations. Optimizing specimen size and controlling ion release could mitigate adverse effects, suggesting further research to balance therapeutic benefits and risks in periodontal tissues.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 44 (4), 456-462, 2025-07-25
一般社団法人 日本歯科理工学会
