Purpose : To investigate postoperative frequency of antiemetic use and pain after emergence from general anesthesia using remimazolam.
Methods : The data of secondary endpoints in a randomized controlled trial that examined memory retention as the primary endpoint after emergence from general anesthesia using remimazolam were used. Patients undergoing breast surgery were enrolled and randomly assigned to receive propofol(control group)or remimazolam as general anesthetics. Antiemetic use immediately after surgery and from the time of returning to the ward until 24 h after surgery was investigated. The dose of analgesic medication administered from when the patient returned to the ward until 24 h after surgery, the patient’s immediate postoperative pain NRS values, and their pain NRS score 24 h after leaving the operating room(OR)were also recorded.
Results : Sixty-six patients(propofol, 32 ; remimazolam, 34)were assessed. Antiemetic use immediately after surgery was comparable(p=0.43)in both groups, but antiemetic use from the time the patient returned to the ward until 24 h after surgery was higher in the remimazolam group(p=0.03). The incidence of administration of analgesic medications from when the patient returned to the ward until 24 h after surgery(p=0.67), immediate postoperative pain NRS values(p=0.74), and pain NRS scores 24 h after leaving the OR(p=0.88)were comparable in both groups. Flumazenil was administered to 10 patients in the remimazolam group. Antiemetic use and pain was similar with and without flumazenil in the remimazolam group.
Conclusions : Remimazolam is less effective than propofol at inhibiting the frequency of antiemetic use. The effect on pain was similar with both anesthetic agents.
"},{"@language":"ja","@value":"【目的】レミマゾラムを用いた全身麻酔からの覚醒後の制吐薬の使用頻度と疼痛について調査すること．【方法】レミマゾラムを用いた全身麻酔からの覚醒後の記憶保持を主要評価項目として検討したランダム化比較試験の副次的評価項目のデータを用いた．対象は乳房手術を受ける患者で，全身麻酔としてプロポフォール（対照群）とレミマゾラムを投与する群に無作為に割り付けられた．手術直後および病棟に戻ってから手術後24時間までの制吐薬の使用量を調査した．また，病棟に戻ってから手術後24時間までに投与された鎮痛薬の量，患者の術直後の疼痛NRS値，病棟に戻ってから手術後24時間の疼痛NRS値も検討した．【結果】全66例（プロポフォール群32例，レミマゾラム群34例）で評価した．手術直後の制吐薬使用量は両群で同等であった（p＝0.43）．患者が病棟に戻ってから手術後24時間までの制吐薬使用量は，プロポフォール群よりレミマゾラム群の方が有意に多かった（p＝0.03）．病棟に戻ってから手術後24時間までの鎮痛薬投与率（p＝0.67），術直後の疼痛NRS値（p＝0.74），病棟に戻ってから手術後24時間の疼痛NRS値（p＝0.88）は両群で同等であった．レミマゾラム群では10例にフルマゼニルが投与された．レミマゾラム群での制吐薬の使用またはNRS値は，フルマゼニルの有無にかかわらず同程度であった．【結論】レミマゾラムの制吐薬の使用頻度を抑制する効果はプロポフォールより有意に低かった．疼痛に対する効果は両麻酔薬で同様であった．
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Ken"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院医学研究院麻酔・蘇生学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410869378866748930","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"前田 愛子"},{"@language":"en","@value":"MAEDA Aiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital"},{"@language":"ja","@value":"九州大学病院麻酔科蘇生科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410869378866748932","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"白水 和宏"},{"@language":"en","@value":"SHIROZU Kazuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Operating Rooms, Kyushu University 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ANESTHESIA"},{"@language":"ja","@value":"日本臨床麻酔学会"}],"prism:publicationDate":"2024-11-15","prism:volume":"44","prism:number":"7","prism:startingPage":"590","prism:endingPage":"598"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/jjsca/44/7/44_590/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2025078882"}],"availableAt":"2024-11-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%AC%E3%83%9F%E3%83%9E%E3%82%BE%E3%83%A9%E3%83%A0","dc:title":"レミマゾラム"},{"@id":"https://cir.nii.ac.jp/all?q=RCT","dc:title":"RCT"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%88%B6%E5%90%90%E8%96%AC","dc:title":"制吐薬"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%96%BC%E7%97%9B","dc:title":"疼痛"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%97%E3%83%AD%E3%83%9D%E3%83%95%E3%82%A9%E3%83%BC%E3%83%AB","dc:title":"プロポフォール"},{"@id":"https://cir.nii.ac.jp/all?q=Pain","dc:title":"Pain"},{"@id":"https://cir.nii.ac.jp/all?q=Antiemetic%20use","dc:title":"Antiemetic 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