Frequency of antiemetic use and pain after anesthesia with remimazolam：An exploratory, randomized, open, propofol-controlled, single-centre clinical trial

DOI Web Site 21 References
  • NOBUKUNI Keiko
    Operating Rooms, Kyushu University Hospital
  • SHIROZU Kazuhiro
    Operating Rooms, Kyushu University Hospital
  • MAEDA Aiko
    Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital
  • MURAKAMI Tomoko
    Department of Anesthesiology and Critical Care Medicine, Kyushu University Hospital
  • HIGASHI Midoriko
    Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University
  • YAMAURA Ken
    Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • レミマゾラムを用いた麻酔後の制吐薬使用頻度と疼痛：単施設プロポフォール対照探索的オープンランダム化臨床試験
Published
2024-11-15
DOI
  • 10.2199/jjsca.44.590
Publisher
THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

Search this article

Description

<p>Purpose : To investigate postoperative frequency of antiemetic use and pain after emergence from general anesthesia using remimazolam.</p><p>Methods : The data of secondary endpoints in a randomized controlled trial that examined memory retention as the primary endpoint after emergence from general anesthesia using remimazolam were used. Patients undergoing breast surgery were enrolled and randomly assigned to receive propofol(control group)or remimazolam as general anesthetics. Antiemetic use immediately after surgery and from the time of returning to the ward until 24 h after surgery was investigated. The dose of analgesic medication administered from when the patient returned to the ward until 24 h after surgery, the patient’s immediate postoperative pain NRS values, and their pain NRS score 24 h after leaving the operating room(OR)were also recorded.</p><p>Results : Sixty-six patients(propofol, 32 ; remimazolam, 34)were assessed. Antiemetic use immediately after surgery was comparable(p=0.43)in both groups, but antiemetic use from the time the patient returned to the ward until 24 h after surgery was higher in the remimazolam group(p=0.03). The incidence of administration of analgesic medications from when the patient returned to the ward until 24 h after surgery(p=0.67), immediate postoperative pain NRS values(p=0.74), and pain NRS scores 24 h after leaving the OR(p=0.88)were comparable in both groups. Flumazenil was administered to 10 patients in the remimazolam group. Antiemetic use and pain was similar with and without flumazenil in the remimazolam group.</p><p>Conclusions : Remimazolam is less effective than propofol at inhibiting the frequency of antiemetic use. The effect on pain was similar with both anesthetic agents.</p>

Journal

References(21)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top