Distribution of domestic cat hepatitis B virus in cholangiocarcinoma and non-neoplastic liver tissue
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- DOSAKA Haruka
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
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- KATO Nanami X
- Laboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- TAGA Kei
- Tokyo Cat Specialists
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- YAMAMOTO Soshin
- Tokyo Cat Specialists
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- KONDO Kaito
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
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- RINGO Rissar Siringo
- Laboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki Graduate School of Medicine and Veterinary Medicine, University of Miyazaki
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- KANEKO Yasuyuki
- Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki
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- HIRAI Takuya
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki Graduate School of Medicine and Veterinary Medicine, University of Miyazaki
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- SAITO Akatsuki
- Laboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki Graduate School of Medicine and Veterinary Medicine, University of Miyazaki Center for Animal Disease Control, University of Miyazaki
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- FUKE Naoyuki
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
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説明
<p>Domestic cat hepatitis B virus (DCHBV), shares similarities with human hepatitis B virus (HBV) which is associated with liver disease. We report the first case of cholangiocarcinoma in a 17-year-old spayed female cat infected with DCHBV and positive for feline immunodeficiency virus. The patient presented with vomiting, anorexia, and an elevated globulin level. Ultrasonography revealed multiple hypoechoic hepatic lesions, and histopathology confirmed cholangiocarcinoma. The tumor exhibited CK7 positivity and HepPar-1 negativity, confirming biliary origin. Quantitative PCR detected DCHBV in the spleen and ascitic fluid, while immunohistochemistry and RNA in situ hybridization revealed viral antigen and mRNA in both tumor and non-tumor liver. The presence of a viral antigen and mRNA in neoplastic tissue suggests a potential role for DCHBV in hepatobiliary carcinogenesis.</p>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ advpub (0), 2026
公益社団法人 日本獣医学会