Background: The potential impacts of polygenic scores (PGS) on health-behavior changes are not fully understood. The Iwate PGS Assessment and Risk Communication Study aims to investigate the effects of reporting PGS-based risk for ischemic stroke on health behaviors.
Methods: Participants wishing to know their PGS-based ischemic stroke risk were recruited from health checkup venues for workers in Iwate Prefecture in 2023. Health checkup data, biospecimens, and questionnaire responses were collected for biochemical testing, genotyping, and storage in the Tohoku Medical Megabank integrated biobank. The risk was calculated using an integrative PGS model for East Asians. Participants were randomly assigned to two groups, and one group received their risk report as the intervention group. The impacts of the risk notification will be investigated in follow-up surveys.
Results: Of 3,599 workers, 2,088 participated in the study (consent rate: 58.0%). The demographic profile of the eligible 2,083 participants was as follows: 80.7% males, and dominance of participants aged 18–29 years (25.2%), in their 30’s (25.3%), and in their 40’s (24.7%). Two hundred participants (9.7%) had a risk of 1.0 as the reference; 57 (2.7%), 927 (44.7%), and 888 (42.9%) participants had 2.1–3.4-, 1.4–1.9-, and <1.0-fold that risk, respectively.
Conclusion: We collected health information and biospecimens from over 2,000 workers and disclosed the PGS-based ischemic stroke risk. Behavioral effects will be evaluated 1 year after disclosure, with follow-up until 2030. As Japan’s first large-scale PGS risk communication study, it will provide initial insights for implementing PGS in personalized preventive medicine.
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410870075604626434","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0002-9531-8008"}],"foaf:name":[{"@language":"en","@value":"Yoshida Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626432","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0003-3001-9936"}],"foaf:name":[{"@language":"en","@value":"Tokutomi Tomoharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626439","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0001-9003-1289"}],"foaf:name":[{"@language":"en","@value":"Suzumori Nobuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626435","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Fukushima Akimune"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410003825185558018","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0002-1264-0684"},{"@type":"NRID","@value":"9000412210425"},{"@type":"NRID","@value":"9000409209822"},{"@type":"NRID","@value":"9000415124111"},{"@type":"NRID","@value":"9000411090334"},{"@type":"NRID","@value":"9000412099693"},{"@type":"NRID","@value":"9000412187427"},{"@type":"NRID","@value":"9000405913139"},{"@type":"NRID","@value":"9000410040781"},{"@type":"NRID","@value":"9000412086259"},{"@type":"NRID","@value":"9000411115163"}],"foaf:name":[{"@language":"en","@value":"Tanno Kozo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626444","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sutoh Yoichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626453","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ohmomo Hideki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626436","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hachiya Tsuyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626455","@type":"Researcher","personIdentifier":[{"@type":"ORCID","@value":"0000-0002-4659-1200"}],"foaf:name":[{"@language":"en","@value":"Kotozaki Yuka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626450","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Toya Yukiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626446","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hasegawa Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626448","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hamanaka Yohei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626456","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nagaie Satoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626449","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kudo Hisaaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626458","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ogishima Soichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626440","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nagami Fuji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626442","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sakurai-Yageta Mika"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626433","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kumada Kazuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626437","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Narita Akira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626451","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Otsuka-Yamasaki Yayoi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626438","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Komaki Shohei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626443","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Minabe Shiori"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626452","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ishigaki Yasushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626459","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yamamoto Masayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tohoku Medical Megabank Organization, Tohoku University"},{"@language":"en","@value":"Graduate School of Medicine, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626447","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Asahi Koichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Medicine, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626454","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Endo Ryujin"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"School of Nursing, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626441","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Shimizu Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410870075604626457","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sasaki Makoto"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University"},{"@language":"en","@value":"Institute for Biomedical Sciences, Iwate Medical University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09175040"},{"@type":"LISSN","@value":"09175040"},{"@type":"EISSN","@value":"13499092"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Epidemiology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ"},{"@language":"en","@value":"Journal of Epidemiology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ"}],"dc:publisher":[{"@language":"en","@value":"Japan Epidemiological Association"},{"@language":"ja","@value":"日本疫学会"}],"prism:publicationDate":"2026-02-05","prism:volume":"36","prism:number":"2","prism:startingPage":"73","prism:endingPage":"84"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/jea/36/2/36_JE20250078/_pdf"}],"availableAt":"2026-02-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ischemic%20stroke","dc:title":"ischemic stroke"},{"@id":"https://cir.nii.ac.jp/all?q=genome%20cohort","dc:title":"genome cohort"},{"@id":"https://cir.nii.ac.jp/all?q=polygenic%20score","dc:title":"polygenic score"},{"@id":"https://cir.nii.ac.jp/all?q=risk%20communication","dc:title":"risk communication"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1900870075604626432","@type":"Project","projectIdentifier":[{"@type":"JGN","@value":"JP21tm0124006"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202634249856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Predisposition to Ischemic Stroke"},{"@value":"Genetic predisposition to ischemic stroke: a polygenic risk score"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236825340800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005521466886016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168767328640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022304969060096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025029620513920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025033657620992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645556631296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294645672337536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polygenic risk scores: from research tools to clinical instruments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294648242028160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755646658560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stroke genetics informs drug discovery and risk prediction across ancestries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360299458646904960","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306504332035968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306504593206912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reference‐Based Standardization Approach Stabilizing Small Batch Risk Prediction via Polygenic Score"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306508663997824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of polygenic risk communication: an observational mobile application-based coronary artery disease study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568468300888704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095067023616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232409144064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Returning individual genomic results to population-based cohort study participants with BRCA1/2 pathogenic variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360583262255748224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of a clinical polygenic risk score assay and reporting workflow"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584345425470464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584346480774912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior: an Observational Follow-up Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360587979137001088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disclosing genetic risk for coronary heart disease: effects on perceived personal control and genetic counseling satisfaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360587979583508096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570910714496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of the Patient Activation Measure (PAM): Conceptualizing and Measuring Activation in Patients and Consumers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869454298098304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effectiveness and feasibility of cardiovascular disease personalized prevention on high polygenic risk score subjects: a randomized controlled pilot study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412891960873856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ten-Year Cerebrovascular Disease Trend Occurrence by Population-based Stroke Registry in an Aging Japan Local Prefecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975844377821312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943832437504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894943974144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RELIABILIGY AND VALIDITY OF THE JAPANESE-LANGUAGE VERSION OF THE IMPACT OF EVENT SCALE-REVISED (IES-R-J): FOUR STUDIES OF DIFFERENT TRAUMATIC EVENTS"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845453089920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269067069184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The personal and clinical utility of polygenic risk scores"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270574203776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The performance of the Japanese version of the K6 and K10 in the World Mental Health Survey Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204474441600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Tohoku Medical Megabank Project: Design and Mission"},{"@value":"The Tohoku Medical Megabank Project: deesign and mission"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288140046336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project"}]},{"@id":"https://cir.nii.ac.jp/crid/1390292085430224640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants"}]},{"@id":"https://cir.nii.ac.jp/crid/1390301396973248640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845702282848000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project"}]},{"@id":"https://cir.nii.ac.jp/crid/1391694356248948992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2015001202"},{"@type":"CROSSREF","@value":"10.2188/jea.je20250078"},{"@type":"PUBMED","@value":"40915896"}]}