The Stimulatory Effects of Cepharanthine on Hair Growth

J-STAGE
  • Jiang Ju
    Department of Dermatology, Juntendo University School of Medicine
  • Ueki Rie
    Dermatology unit, Juntendo Tokyo Koto Geriatric Medical Center
  • Kuhara Takatoshi
    Atopy (Allergy) Reserch Center, Juntendo University School of Medicine
  • Ikeda Shigaku
    Department of Dermatology, Juntendo University School of Medicine
  • Ogawa Hideoki
    Department of Dermatology, Juntendo University School of Medicine

Bibliographic Information

Other Title
  • Ｃｅｐｈａｒａｎｔｈｉｎｅの毛成長促進作用の検討

Abstract

Cepharanthine (CE) is a biscoclaurine alkaloid obtained from the plant, Stephania Cepharantha Hayata. CE has been known to have a vasodilatory effect and has been used for the treatment of alopecia areata in Japan. However, the exact mechanism of CE's effect on hair growth has not been clarified.<BR>In this study, we analyzed the effect of CE on hair growth stimulation in a C3H/HeN mouse system in vivo. We also analyzed the effects of CE on cell proliferation of dermal papilla cells (DPCs) and outer root sheath cells (ORSCs) in vitro preliminarily.<BR>For quantitative evaluation of hair growth in mice, 0.002% CE solution or vehicle solution (75% alcohol) were applied to the dorsum of the 8 weeks old C3H/HeN mice once daily for three weeks, after clipping the dorsal resting hair. A significant stimulatory effect on hair growth of mice treated with CE was seen compared with the vehicle treated group (p<0.05, n=10). In addition, 0.1μg/ml CE stimulated cell proliferation of cultured DPCs (p<0.05), but not that of cultured ORSCs.<BR>These results confirmed that CE has a stimulatory effect on hair growth in vivo. CE might have an effect on DPCs directly.

Journal

  • Skin research

    Skin research 4 (2), 99-103, 2005

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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