Metabolism of remnant lipoprotein after oral fat loading

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  • 脂肪負荷後レムナント代謝について

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In the previous study we clarified that postprandial lipid metabolism was delayed in individuals with visceral fat accumulation. In the present study, we investigated how abdominal visceral fat accumulation affected postprandial remnat lipoprotein metabolism.<br>Subjects with obesity and visceral fat area/subcutaneous fat area>0.4, or those without obesity and visceral fat area>100cm2 for male (>90cm2 for female) were defined as visceral fat accumulation(VFA). Midband lipoproteins analyzed by PAGE and plasma IDL-C levels determined by ultracentrifugation were used as indicators of remnant lipoproteins.<br>Individuals with VFA had midband lipoprotein more frequently and higher plasma levels of IDL-C both at 0 and 4 hours after oral fat loading than those without VFA.<br>These results suggest that accumulation of abdominal visceral fat causes delayed metabolism of plasma remnant lipoprotein, which may lead to the development of coronary atherosclerosis.

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