{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1573387452273706752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"NAID","@value":"110003654821"}}],"dc:title":[{"@language":"en","@value":"Synthesis of 2,3-Dihydro-1,4-benzodioxin Derivatives. I. : 2-Substituted-5(and 6)-sulfamoyl-2,3-dihydro-1,4-benzodioxins"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"In order to study new sulfonamide diuretics, two series of 6- and 5-sulfamoyl-2,3-dihydro-1,4-benzodioxins were synthesized and tested for diuretic and antihypertensive activities in rats. Starting from 4-chloro(or 3,4-dichloro)-1,2-dihydroxybenzene, these sulfamoyl compounds were prepared by two different routes. In method A, 6-sulfamoyl compounds (8 or 11) were obtained by conversion of the nitro function into sulfonamide via the Sandmeyer reaction. In method B, 5-sulfamoyl compounds (16) were synthesized by direct introduction of sulfonyl chloride into the dihydrobenzodioxin, followed by amination. The sulfamoyl dihydrobenzodioxins showed lower diuretic and antihypertensive activities than trichloromethiazide."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1583387452273704448","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005170359"}],"foaf:name":[{"@language":"ja","@value":"板崎 弘"},{"@language":"en","@value":"ITAZAKI HIROSHI"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]},{"@id":"https://cir.nii.ac.jp/crid/1583387452273706753","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005276934"}],"foaf:name":[{"@language":"ja","@value":"川崎 明子"},{"@language":"en","@value":"KAWASAKI AKIKO"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]},{"@id":"https://cir.nii.ac.jp/crid/1583387452273704449","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005276935"}],"foaf:name":[{"@language":"ja","@value":"松浦 宗教"},{"@language":"en","@value":"MATSUURA MUNENORI"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]},{"@id":"https://cir.nii.ac.jp/crid/1583387452273706757","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004465197"}],"foaf:name":[{"@language":"ja","@value":"上田 元彦"},{"@language":"en","@value":"UEDA MOTOHIKO"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]},{"@id":"https://cir.nii.ac.jp/crid/1581980077392563329","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005171354"}],"foaf:name":[{"@language":"ja","@value":"米谷 行男"},{"@language":"en","@value":"YONETANI YUKIO"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]},{"@id":"https://cir.nii.ac.jp/crid/1580572702506907779","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018307874"}],"foaf:name":[{"@language":"ja","@value":"中村 益久"},{"@language":"en","@value":"NAKAMURA MASUHISA"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shionogi Research Laboratories, Shionogi & Co., Ltd.,"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"00092363"},{"@type":"NCID","@value":"AA00602100"}],"prism:publicationName":[{"@language":"en","@value":"Chemical & pharmaceutical bulletin"}],"dc:publisher":[{"@value":"公益社団法人日本薬学会"},{"@language":"en","@value":"The Pharmaceutical Society of Japan"}],"prism:publicationDate":"1988-09-25","prism:volume":"36","prism:number":"9","prism:startingPage":"3387","prism:endingPage":"3403"},"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=sulfonamide%20diuretic","dc:title":"sulfonamide diuretic"},{"@id":"https://cir.nii.ac.jp/all?q=2,%203-dihydro-1,%204-benzodioxin","dc:title":"2, 3-dihydro-1, 4-benzodioxin"},{"@id":"https://cir.nii.ac.jp/all?q=phenoxyacetic%20acid","dc:title":"phenoxyacetic acid"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B1-blocker","dc:title":"α-blocker"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B2-blocker","dc:title":"β-blocker"},{"@id":"https://cir.nii.ac.jp/all?q=antihypertensive","dc:title":"antihypertensive"},{"@id":"https://cir.nii.ac.jp/all?q=uricosuric","dc:title":"uricosuric"},{"@id":"https://cir.nii.ac.jp/all?q=sulfonamide%20diuretic","dc:title":"sulfonamide diuretic"},{"@id":"https://cir.nii.ac.jp/all?q=2,%203-dihydro-1,%204-benzodioxin","dc:title":"2, 3-dihydro-1, 4-benzodioxin"},{"@id":"https://cir.nii.ac.jp/all?q=phenoxyacetic%20acid","dc:title":"phenoxyacetic acid"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B1-blocker","dc:title":"α-blocker"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B2-blocker","dc:title":"β-blocker"},{"@id":"https://cir.nii.ac.jp/all?q=antihypertensive","dc:title":"antihypertensive"},{"@id":"https://cir.nii.ac.jp/all?q=uricosuric","dc:title":"uricosuric"}],"dataSourceIdentifier":[{"@type":"CIA","@value":"110003654821"}]}