{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1573387452900737664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"NAID","@value":"130003542309"}},{"identifier":{"@type":"URI","@value":"https://jlc.jst.go.jp/DN/JALC/00150470425?from=CiNii"}}],"dc:title":[{"@language":"en","@value":"Quantitative determination of bile acid glucuronides in serum by mass fragmentography."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Individual non-glucuronidated•non-sulfated, glucuronidated and sulfated bile acids in serum were determined, <i>i.e.</i> lithocholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid, and cholic acid, by mass fragmentography. Glucuronic acid conjugates of lithocholic acid, deoxycholic acid, chenodeoxycholic acid, and cholic acid were synthesized <i>via</i> the Koenigs-Knorr condensation reaction. Deute-rium labeled deoxycholic acid, lithocholic acid glucuronide, deoxycholic acid glucu-ronide, and deoxycholic acid sulfate were synthesized and used as internal standards. A serum sample of 1 ml including internal standards was purified with a Sep-Pak <i>C</i><sub>18</sub> cartridge. After the enzymatic cleavage of amino acid conjugates, bile acids were separated into three fractions, free, glucuronidated, and sulfated bile acids, using piperidinohydroxypropyl Sephadex LH-20 (Goto <i>et al.</i> (1978) <i>Clin. Chim. Acta</i> 87). Glucuronidated and sulfated bile acids were deconjugated by β-glucuronidase treat-ment and solvolysis. Each fraction was converted to the hexafluoroisopropyl-tri-fluoroacetyl derivative and quantitated by mass fragmentography. The average concentrations of individual bile acid glucuronides from healthy fasting subjects (<i>n</i>=9) were as follows; lithocholic acid 0.013μg/ml, deoxycholic acid 0.083μg/ml, chenodeoxycholic acid 0.078μg/ml, ursodeoxycholic acid 0.013μg/ml, and cholic acid 0.007μg/ml. Bile acid glucuronides occupied 7.8% of the total bile acids."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326223484800","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70197226"},{"@type":"NRID","@value":"1000070197226"},{"@type":"NRID","@value":"9000248229209"},{"@type":"NRID","@value":"9000000387779"},{"@type":"NRID","@value":"9000001504391"},{"@type":"NRID","@value":"9000107385461"},{"@type":"NRID","@value":"9000402293219"},{"@type":"NRID","@value":"9000021889477"},{"@type":"NRID","@value":"9000404121521"},{"@type":"NRID","@value":"9000391623629"},{"@type":"NRID","@value":"9000253206209"},{"@type":"NRID","@value":"9000000902394"},{"@type":"NRID","@value":"9000016417400"},{"@type":"NRID","@value":"9000016418525"},{"@type":"NRID","@value":"9000011077870"},{"@type":"NRID","@value":"9000107396781"},{"@type":"NRID","@value":"9000001434671"},{"@type":"NRID","@value":"9000001669465"},{"@type":"NRID","@value":"9000002003900"},{"@type":"NRID","@value":"9000016418276"},{"@type":"NRID","@value":"9000347077785"},{"@type":"NRID","@value":"9000016417999"},{"@type":"NRID","@value":"9000248229309"},{"@type":"NRID","@value":"9000248229851"},{"@type":"NRID","@value":"9000414837690"},{"@type":"NRID","@value":"9000257904595"},{"@type":"NRID","@value":"9000001539679"},{"@type":"NRID","@value":"9000002073783"},{"@type":"NRID","@value":"9000261676286"},{"@type":"NRID","@value":"9000253203311"},{"@type":"NRID","@value":"9000253110544"},{"@type":"NRID","@value":"9000018796398"},{"@type":"NRID","@value":"9000248229405"},{"@type":"NRID","@value":"9000014173249"},{"@type":"NRID","@value":"9000021433650"},{"@type":"NRID","@value":"9000391617419"},{"@type":"NRID","@value":"9000001503850"},{"@type":"NRID","@value":"9000021327035"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0030537"}],"foaf:name":[{"@language":"en","@value":"TAKIKAWA 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