Synthesis and Application of Imidazole Derivatives. Synthesis and Acyl Activation of 2-Acyl-1-methyl-1H-imidazoles(Organic,Chemical)

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Description

2-Acyl-1-methyl-1 H-imidazoles (3) were prepared in good yields by treating 1-acylpyrrolidines (5) with 2-lithio-1-methyl-1 H-imidazole (2) at -78℃. The acyl group of 3 was very stable under various severe conditions, but 2-benzoylimidazole (3a) was gradually hydrolyzed by heating with 1.3_N NaOH to produce benzoic acid and 1-methyl-1 H-imidazole. Acyl activation of 3 was performed by direct quaternization of 3 with iodomethane or dimethyl sulfate or more successfully by quaternization of the corresponding O-trimethylsilylated gcm-cyanohydrin (11) with dimethyl sulfatts.

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Details 詳細情報について

  • CRID
    1573668927092397312
  • NII Article ID
    110006280818
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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