{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1871428067723311488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/molecules181215724"}},{"identifier":{"@type":"PMID","@value":"24352025"}}],"dc:title":[{"@value":"Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation"}],"description":[{"notation":[{"@value":"<jats:p>Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and  anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes.  The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1891428067723311489","@type":"Researcher","foaf:name":[{"@value":"Jung-A Lee"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067723311488","@type":"Researcher","foaf:name":[{"@value":"Jang-Hyun Kim"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067723311490","@type":"Researcher","foaf:name":[{"@value":"Eunsun Jung"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067723311491","@type":"Researcher","foaf:name":[{"@value":"Seoungwoo Shin"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067723311492","@type":"Researcher","foaf:name":[{"@value":"Deokhoon Park"}]},{"@id":"https://cir.nii.ac.jp/crid/1891428067723311493","@type":"Researcher","foaf:name":[{"@value":"Kyung-Baeg Roh"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14203049"}],"prism:publicationName":[{"@value":"Molecules"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2013-12-16","prism:volume":"18","prism:startingPage":"15724","prism:endingPage":"15736"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Keratinocytes","dc:title":"Keratinocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Ultraviolet%20Rays","dc:title":"Ultraviolet Rays"},{"@id":"https://cir.nii.ac.jp/all?q=madecassoside","dc:title":"madecassoside"},{"@id":"https://cir.nii.ac.jp/all?q=post-inflammatory%20pigmentation;%20madecassoside;%20PAR-2;%20UVR","dc:title":"post-inflammatory pigmentation; madecassoside; PAR-2; UVR"},{"@id":"https://cir.nii.ac.jp/all?q=Organic%20chemistry","dc:title":"Organic chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=PAR-2","dc:title":"PAR-2"},{"@id":"https://cir.nii.ac.jp/all?q=UVR","dc:title":"UVR"},{"@id":"https://cir.nii.ac.jp/all?q=Dinoprost","dc:title":"Dinoprost"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Dinoprostone","dc:title":"Dinoprostone"},{"@id":"https://cir.nii.ac.jp/all?q=QD241-441","dc:title":"QD241-441"},{"@id":"https://cir.nii.ac.jp/all?q=Phagocytosis","dc:title":"Phagocytosis"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Melanins","dc:title":"Melanins"},{"@id":"https://cir.nii.ac.jp/all?q=post-inflammatory%20pigmentation","dc:title":"post-inflammatory pigmentation"},{"@id":"https://cir.nii.ac.jp/all?q=Coculture%20Techniques","dc:title":"Coculture Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Triterpenes","dc:title":"Triterpenes"},{"@id":"https://cir.nii.ac.jp/all?q=Biosynthetic%20Pathways","dc:title":"Biosynthetic Pathways"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclooxygenase%202","dc:title":"Cyclooxygenase 2"},{"@id":"https://cir.nii.ac.jp/all?q=Melanocytes","dc:title":"Melanocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Epidermis","dc:title":"Epidermis"}],"dataSourceIdentifier":[{"@type":"OPENAIRE","@value":"doi_dedup___::2272e4477b06ab9a096903ed5d05024e"}]}