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Description
The nutritional status plays a pivotal role during anticancer therapy. This study analyzed whether nutritional status influences the outcomes in the era of FOLFOX/FIRI therapy.The patients were divided into two groups according to whether the nutritional status was well (serum albumin level ≥ 3.8 g/dL or a ≥ 1.0 g/dL increase as compared with the value before chemotherapy) or not before and 2 and 6 months after the start of chemotherapy. Chemotherapy-related adverse events (AE), treatment effect, and compliance were evaluated according to the nutritional status. The progression-free survival (PFS) and overall survival (OS) were assessed based on the nutritional status at 6 months.Between 2010 and 2013, data on 108 consecutive patients were analyzed. At 2 months after chemotherapy, the hematotoxicic AE and the value of tumor markers did not differ significantly. The non-hematotoxic AE were less frequent in patients in the well-nourished group (grade 2, 15.9 vs. 38.5%, p 0.01). Based on the nutritional status at 6 months after chemotherapy, the hematotoxicic AE (grade 3, 9 vs. 19.5%, p = 0.03) and non-hematotoxic AE (grade 2, 31.3 vs. 51.2%, p = 0.04; grade 3, 6.0 vs. 24.4%, p 0.01) were less frequent, and the median CEA value (5.3 vs. 27.75 mg/L, p 0.01) was significantly lower in the well-nourished group. The median PFS (364 vs. 233 days, p 0.01) and 5-year OS (26.5 vs. 11.1%, p = 0.01) are significantly better in the well-nourished group.The well-nourished at initial 6 months may predict a better treatment response and fewer adverse events in FOLFOX/FIRI chemotherapy.
Journal
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- World Journal of Surgical Oncology
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World Journal of Surgical Oncology 15 2017-08-24
Springer Science and Business Media LLC
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Keywords
- Adult
- Male
- RD1-811
- Organoplatinum Compounds
- Leucovorin
- Nutritional Status
- Disease-Free Survival
- Antineoplastic Combined Chemotherapy Protocols
- Chemotherapy
- Humans
- RC254-282
- Serum Albumin
- Nutrition
- Aged
- Aged, 80 and over
- Research
- Malnutrition
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
- Middle Aged
- Prognosis
- Colorectal cancer
- Treatment Outcome
- Surgery
- Camptothecin
- Female
- Fluorouracil
- Colorectal Neoplasms
- Follow-Up Studies