{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1873679867366750080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"PMID","@value":"34693906"}}],"dc:title":[{"@value":"Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the"}],"description":[{"notation":[{"@value":"Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit refinement to learning and memory. Astrocytes also express NMDARs, although their exact function has remained controversial. Here, we identify in mouse hippocampus, a circuit function for GluN2C NMDAR, a subtype highly expressed in astrocytes, in layer-specific tuning of synaptic strengths in CA1 pyramidal neurons. Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1891992115625853442","@type":"Researcher","foaf:name":[{"@value":"Sunita, Ghimire Gautam"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853448","@type":"Researcher","foaf:name":[{"@value":"Mizuki, Kurosawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853440","@type":"Researcher","foaf:name":[{"@value":"Manabu, Abe"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853449","@type":"Researcher","foaf:name":[{"@value":"Kenji, Sakimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853450","@type":"Researcher","foaf:name":[{"@value":"Tomoki, Fukai"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853447","@type":"Researcher","foaf:name":[{"@value":"Yukiko, Goda"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853451","@type":"Researcher","foaf:name":[{"@value":"Atsushi, Kawai"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853441","@type":"Researcher","foaf:name":[{"@value":"Alejandra, Pazo Fernandez"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853443","@type":"Researcher","foaf:name":[{"@value":"Abhilash, Sawant"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853445","@type":"Researcher","foaf:name":[{"@value":"Peter H, Chipman"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853444","@type":"Researcher","foaf:name":[{"@value":"Angelo, Tedoldi"}]},{"@id":"https://cir.nii.ac.jp/crid/1891992115625853446","@type":"Researcher","foaf:name":[{"@value":"Chi Chung Alan, Fung"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"2050084X"}],"prism:publicationName":[{"@value":"eLife"}],"prism:publicationDate":"2021-05-31","prism:volume":"10"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Neuronal%20Plasticity","dc:title":"Neuronal Plasticity"},{"@id":"https://cir.nii.ac.jp/all?q=Pyramidal%20Cells","dc:title":"Pyramidal Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=CA1%20Region,%20Hippocampal","dc:title":"CA1 Region, Hippocampal"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20N-Methyl-D-Aspartate","dc:title":"Receptors, N-Methyl-D-Aspartate"}],"dataSourceIdentifier":[{"@type":"OPENAIRE","@value":"pmid________::4b3b8c37ac5d4dc79f13a0dc0d3fa690"}]}