{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1881428068096799616.json","@type":"Dataset","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.5230417"}},{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.5230417.v1"}}],"dc:title":[{"@value":"Supplementary Material for: Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma"}],"description":[{"notation":[{"@value":"<b><i>Background/Aims:</i></b> Gastric adenocarcinoma of fundic gland type (GAFG), which is a rare variant of gastric cancer, is reportedly associated with both Wnt/β-catenin signaling activation and guanine nucleotide binding protein, alpha stimulating complex (<i>GNAS</i>) mutations. This study aimed to elucidate potential roles of the Sonic hedgehog (Shh) signaling pathway in GAFG. <b><i>Methods:</i></b> We performed immunostaining for β-catenin and Shh signal-associated proteins, including Patched (Ptch), Smoothened (Smo), and Glioma-associated oncogene-1 (Gli1), and the direct sequencing of <i>GNAS</i>/<i>BRAF</i>/<i>KRAS</i> in 27 GAFGs, and compared them with 30 conventional gastric adenocarcinomas (CGAs). <b><i>Results:</i></b> GAFGs exhibited significantly lower immunoreactivity scores for Ptch, Smo, and Gli1 than CGAs. Moreover, while the Ptch score was significantly lower in the GAFG tumor areas than in the non-neoplastic areas adjacent to GAFG, the score was significantly higher in the CGA tumor areas than in the non-neoplastic areas. Similar trends were observed in the scores for Smo and Gli1. β-Catenin expression and <i>GNAS</i> mutations were found in 22 (81%) and 8 (30%) of the 27 GAFGs respectively. Gli1 expression was significantly associated with mutations in <i>GNAS</i>. <b><i>Conclusion:</i></b> GAFG and CGA exhibited distinct Ptch, Smo, and Gli1 expression patterns. Downregulation of the Shh signaling pathway, as well as activation of the Wnt/β-catenin signaling pathway, may therefore be associated with tumorigenesis in GAFG."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1891428068096799624","@type":"Researcher","foaf:name":[{"@value":"Tajima, Y."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799619","@type":"Researcher","foaf:name":[{"@value":"Saito, T."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799623","@type":"Researcher","foaf:name":[{"@value":"Murakami, T."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799616","@type":"Researcher","foaf:name":[{"@value":"Hiromoto, T."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799618","@type":"Researcher","foaf:name":[{"@value":"Akazawa, Y."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799621","@type":"Researcher","foaf:name":[{"@value":"Sasahara, N."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799622","@type":"Researcher","foaf:name":[{"@value":"Yao, T."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799617","@type":"Researcher","foaf:name":[{"@value":"Watanabe, S."}]},{"@id":"https://cir.nii.ac.jp/crid/1891428068096799620","@type":"Researcher","foaf:name":[{"@value":"Mitomi, H."}]}],"publication":{"dc:publisher":[{"@value":"Karger Publishers"}],"prism:publicationDate":"2017-01-01"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360857597430427648","@type":"Article","relationType":["isSupplementTo"],"jpcoar:relatedTitle":[{"@value":"Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma"}]}],"dataSourceIdentifier":[{"@type":"OPENAIRE","@value":"doi_dedup___::93f8a11262ed40aacffec6295ac5b7c4"}]}