{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/2051714792015453440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"NDL_BIB_ID","@value":"12686239"}},{"identifier":{"@type":"DOI","@value":"10.1007/s10157-022-02196-y"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/digimeta/12686239"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/12686239"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s10157-022-02196-y.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s10157-022-02196-y/fulltext.html"}},{"identifier":{"@type":"PMID","@value":"35212881"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Hsp70 promotes maturation of uromodulin mutants that cause familial juvenile hyperuricemic nephropathy and suppresses cellular damage"}],"dcterms:alternative":[{"@value":"Hsp70 promotes maturation of uromodulin mutants that cause familial juvenile hyperuricemic nephropathy and suppresses cellular damage"}],"dc:language":"en","description":[{"notation":[{"@value":"収集根拠 : オンライン資料収集制度"},{"@value":"資料形態 : テキストデータ"},{"@value":"コレクション : 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/2061714792015453441","@type":"Researcher","foaf:name":[{"@value":"Sulistiyati Bayu Utami"}]},{"@id":"https://cir.nii.ac.jp/crid/2061714792015453440","@type":"Researcher","foaf:name":[{"@value":"Ryo Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/2061714792015453442","@type":"Researcher","foaf:name":[{"@value":"Toshihiro Hamada"}]}],"publication":{"publicationIdentifier":[{"@type":"ISSN","@value":"14377799"},{"@type":"LISSN","@value":"14377799"},{"@type":"PISSN","@value":"13421751"},{"@type":"EISSN","@value":"14377799"}],"prism:publicationName":[{"@value":"Clinical and experimental nephrology : official publication of the Japanese Society of Nephrology"}],"dc:publisher":[{"@value":"Japanese Society of Nephrology"}],"prism:publicationDate":"2022-02-25","prism:volume":"26(6)","prism:startingPage":"522","prism:endingPage":"529"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/digimeta/12686239"},{"@id":"https://dl.ndl.go.jp/pid/12686239"},{"@id":"https://link.springer.com/content/pdf/10.1007/s10157-022-02196-y.pdf"},{"@id":"https://link.springer.com/article/10.1007/s10157-022-02196-y/fulltext.html"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=HEK293%20Cells","dc:title":"HEK293 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Gout","dc:title":"Gout"},{"@id":"https://cir.nii.ac.jp/all?q=Uromodulin","dc:title":"Uromodulin"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Diseases","dc:title":"Kidney Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Hyperuricemia","dc:title":"Hyperuricemia"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis%20Regulatory%20Proteins","dc:title":"Apoptosis Regulatory Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Pedigree","dc:title":"Pedigree"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040010457607307008","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K06085"},{"@type":"JGN","@value":"JP22K06085"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06085/"}],"notation":[{"@language":"ja","@value":"人工染色体技術を活用した脆弱X症候群関連染色体脆弱部位の機能解析とモデル系の構築"},{"@language":"en","@value":"Construction of model systems  for functional analysis of chromosomal fragile sites associated with fragile X syndrome using artificial chromosome technology"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256976225920","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K06183"},{"@type":"JGN","@value":"JP18K06183"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06183/"}],"notation":[{"@language":"ja","@value":"人工染色体へのFXS脆弱部位の搭載とCGGリピート不安定化再現モデルの作製"},{"@language":"en","@value":"Chromosomal cloning of FXS-related chromosomal fragile site including pathongenic CGG triplet repeat"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145585514112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ER stress and the unfolded protein response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146267339008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016869875447424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619270503552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"UROMODULIN Mutations Cause Familial Juvenile Hyperuricemic Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621121304448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621257568256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298344097811968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Localization of the Tamm‐Horsfall glycoprotein (unomodulin) gene to chromosome 16p12.3‐16p13.11"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095915125760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579815842001920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum Stress in UMOD-Related Kidney Disease: A Human Pathologic Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579817462268928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044397717632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)‐1 stabilizes K<sub>v</sub>1.5 channels in HL‐1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519247301248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Human Uromodulin as the Tamm-Horsfall Urinary Glycoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994683411328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intracellular transport, cell-surface exposure and release of recombinant Tamm-Horsfall glycoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468408394240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein Oligomerization in the Endoplasmic Reticulum"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468459677952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutant Tamm-Horsfall Glycoprotein Accumulation in Endoplasmic Reticulum Induces Apoptosis Reversed by Colchicine and Sodium 4-Phenylbutyrate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469833932800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification and characterization of D8C, a novel domain present in liver‐specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471078920192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective Intracellular Trafficking of Uromodulin Mutant Isoforms"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944880081024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Heat Shock Proteins 27 and 70: Anti-Apoptotic Proteins with Tumorigenic Properties"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946288281728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biochemical and Mechanical Dysfunction in a Mouse Model of Desmin-Related Myopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371356246016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Uromodulin storage disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845208220416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ubiquitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845234101504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318607705088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of HSP70 promotes ΔF508 CFTR trafficking"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794870951424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796011876352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tamm–Horsfall protein or uromodulin: new ideas about an old molecule"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205246172416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reciprocal Control of hERG Stability by Hsp70 and Hsc70 with Implication for Restoration of LQT2 Mutant Stability"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317027809536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat"}]}],"dataSourceIdentifier":[{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R100000039-I12686239"},{"@type":"CROSSREF","@value":"10.1007/s10157-022-02196-y"},{"@type":"KAKEN","@value":"PRODUCT-23669610"},{"@type":"KAKEN","@value":"PRODUCT-24254479"},{"@type":"OPENAIRE","@value":"doi_dedup___::09e0b68c3c5eaaebc0cd4590a117bd42"}]}