{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/2120307889983799296.json","@type":"OtherWorks","productIdentifier":[{"identifier":{"@type":"HDL","@value":"https://hdl.handle.net/2324/7237127"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2000030232"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Fas and Nicotinic Acetylcholine Receptor in Human Myasthenic Thymus: Immunohistochemical Study"},{"@language":"ja","@value":"重症筋無力症胸腺におけるニコチン性アセチルコリン受容体とFasの発現について : 免疫組織化学的検討"}],"dc:language":"en","description":[{"type":"Abstract","notation":[{"@language":"en","@value":"We studied the immunohistochemical localization of Fas and nicotinic acetylcholine receptor (nAChR) in the human thymus with myasthenia gravis (MG). Thymuses were obtained from thirteen patients with MG, (thymic hyperplasia 8; thymoma 5) and six normal controls. Antibodies against Fas, nAChR protein isolated from fetal calf thymus (nAChR-FCT), CD3, CD4, and CDS were used. In both hyperplastic thymus and controls, Fas antigen was found in medullary epithelial cells especially in those around Hassall's corpuscle, in subcapsular epithelial cells, and partially in the cortex. There were no apparent differences between myasthenic thymus and the controls. In the thymic medulla the anti-nAChR-FCT antibody showed a similar staining pattern to the antibody against Fas. The nAChR and the Fas were suggested to be present in the same cell. Then six thymomas were double immunostained with antibodies against Fas and nAChR-FCT. A part of neoplastic epithelial cells were double positive for both Fas and nAChR. The present results show the first observation on the colocalization of the Fas and nAChR in thymic epithelial cells. These antigens were supposed to work on triggering mechanism of autoimmunity in MG."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658352857088","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70037472"},{"@type":"NRID","@value":"1000070037472"},{"@type":"NRID","@value":"9000007734859"},{"@type":"NRID","@value":"9000363351122"},{"@type":"NRID","@value":"9000018015944"},{"@type":"NRID","@value":"9000002873906"},{"@type":"NRID","@value":"9000018072160"}],"foaf:name":[{"@language":"en","@value":"KAWANAMI, Sachiko"},{"@language":"ja","@value":"川浪, 祥子"},{"@language":"ja-Kana","@value":"カワナミ, サチコ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Internal Medicine, Fukuoka University, School of Medicine"},{"@language":"ja","@value":"福岡大学医学部内科第一（神経）"},{"@language":"en","@value":"Department of Internal Medicine & Health Care, Fukuoka University, School of Medicine"},{"@language":"ja","@value":"福岡大学医学部内科（含健管）"}]},{"@id":"https://cir.nii.ac.jp/crid/1070307889983799299","@type":"Researcher","foaf:name":[{"@language":"en","@value":"MORI, Syoichirou"},{"@language":"ja","@value":"森, 尚一郎"},{"@language":"ja-Kana","@value":"モリ, ショウイチロウ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Internal Medicine, Fukuoka University, School of Medicine"},{"@language":"ja","@value":"福岡大学医学部内科第一（神経）"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658314426370","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80078774"},{"@type":"NRID","@value":"1000080078774"}],"foaf:name":[{"@language":"en","@value":"KIKUCHI, Masahiro"},{"@language":"ja","@value":"菊池, 昌弘"},{"@language":"ja-Kana","@value":"キクチ, マサヒロ"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Pathology, Fukuoka University, School of Medicine"},{"@language":"ja","@value":"福岡大学医学部病理学第一"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658311079168","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20038863"},{"@type":"NRID","@value":"1000020038863"},{"@type":"NRID","@value":"9000002871062"},{"@type":"NRID","@value":"9000002858937"},{"@type":"NRID","@value":"9000018301236"},{"@type":"NRID","@value":"9000004684281"},{"@type":"NRID","@value":"9000018199176"},{"@type":"NRID","@value":"9000253603322"},{"@type":"NRID","@value":"9000253565027"},{"@type":"NRID","@value":"9000253389247"},{"@type":"NRID","@value":"9000256628702"},{"@type":"NRID","@value":"9000014358486"},{"@type":"NRID","@value":"9000007156493"},{"@type":"NRID","@value":"9000001578758"},{"@type":"NRID","@value":"9000254175738"},{"@type":"NRID","@value":"9000254179424"},{"@type":"NRID","@value":"9000257918842"},{"@type":"NRID","@value":"9000256627432"},{"@type":"NRID","@value":"9000008813202"},{"@type":"NRID","@value":"9000004569244"},{"@type":"NRID","@value":"9000252891607"},{"@type":"NRID","@value":"9000254179782"},{"@type":"NRID","@value":"9000253565575"},{"@type":"NRID","@value":"9000254624247"},{"@type":"NRID","@value":"9000253348294"},{"@type":"NRID","@value":"9000258071945"},{"@type":"NRID","@value":"9000256633239"},{"@type":"NRID","@value":"9000046108728"},{"@type":"NRID","@value":"9000254175386"},{"@type":"NRID","@value":"9000253622274"},{"@type":"NRID","@value":"9000253582028"},{"@type":"NRID","@value":"9000253349521"},{"@type":"NRID","@value":"9000253374300"},{"@type":"NRID","@value":"9000258104286"},{"@type":"NRID","@value":"9000007449327"},{"@type":"NRID","@value":"9000254620497"},{"@type":"NRID","@value":"9000021473780"},{"@type":"NRID","@value":"9000021855115"},{"@type":"NRID","@value":"9000391409307"},{"@type":"NRID","@value":"9000253579960"},{"@type":"NRID","@value":"9000253587931"},{"@type":"NRID","@value":"9000253580426"},{"@type":"NRID","@value":"9000253579678"},{"@type":"NRID","@value":"9000000578260"},{"@type":"NRID","@value":"9000006196680"},{"@type":"NRID","@value":"9000253595413"},{"@type":"NRID","@value":"9000253601306"},{"@type":"NRID","@value":"9000252908321"},{"@type":"NRID","@value":"9000252899572"},{"@type":"NRID","@value":"9000257919026"},{"@type":"NRID","@value":"9000283520864"},{"@type":"NRID","@value":"9000009994463"},{"@type":"NRID","@value":"9000253584578"},{"@type":"NRID","@value":"9000253612122"},{"@type":"NRID","@value":"9000253501528"},{"@type":"NRID","@value":"9000254622430"},{"@type":"NRID","@value":"9000254624979"},{"@type":"NRID","@value":"9000258604915"},{"@type":"NRID","@value":"9000002131421"},{"@type":"NRID","@value":"9000020631895"},{"@type":"NRID","@value":"9000020143087"},{"@type":"NRID","@value":"9000018196750"},{"@type":"NRID","@value":"9000254625826"},{"@type":"NRID","@value":"9000252908640"},{"@type":"NRID","@value":"9000257773459"},{"@type":"NRID","@value":"9000020053683"},{"@type":"NRID","@value":"9000020053415"},{"@type":"NRID","@value":"9000022175595"},{"@type":"NRID","@value":"9000022137504"},{"@type":"NRID","@value":"9000253565725"},{"@type":"NRID","@value":"9000253565614"},{"@type":"NRID","@value":"9000403545056"},{"@type":"NRID","@value":"9000257920175"},{"@type":"NRID","@value":"9000257918420"},{"@type":"NRID","@value":"9000254624588"},{"@type":"NRID","@value":"9000022114326"},{"@type":"NRID","@value":"9000020574518"},{"@type":"NRID","@value":"9000253585589"},{"@type":"NRID","@value":"9000252855037"},{"@type":"NRID","@value":"9000253564980"},{"@type":"NRID","@value":"9000255788516"},{"@type":"NRID","@value":"9000241846734"},{"@type":"NRID","@value":"9000006775984"},{"@type":"NRID","@value":"9000254177489"},{"@type":"NRID","@value":"9000254625715"},{"@type":"NRID","@value":"9000253448393"},{"@type":"NRID","@value":"9000253565011"},{"@type":"NRID","@value":"9000253300738"},{"@type":"NRID","@value":"9000009885038"},{"@type":"NRID","@value":"9000252850833"},{"@type":"NRID","@value":"9000257920037"},{"@type":"NRID","@value":"9000001676929"},{"@type":"NRID","@value":"9000364905460"},{"@type":"NRID","@value":"9000364868366"},{"@type":"NRID","@value":"9000254179435"},{"@type":"NRID","@value":"9000257918572"},{"@type":"NRID","@value":"9000008590723"},{"@type":"NRID","@value":"9000254620761"},{"@type":"NRID","@value":"9000253579388"},{"@type":"NRID","@value":"9000253602566"},{"@type":"NRID","@value":"9000253596851"},{"@type":"NRID","@value":"9000252911525"},{"@type":"NRID","@value":"9000253358589"},{"@type":"NRID","@value":"9000253378576"},{"@type":"NRID","@value":"9000254621080"},{"@type":"NRID","@value":"9000021764547"},{"@type":"NRID","@value":"9000253593795"},{"@type":"NRID","@value":"9000253581140"},{"@type":"NRID","@value":"9000253356375"},{"@type":"NRID","@value":"9000255886960"},{"@type":"NRID","@value":"9000347126279"},{"@type":"NRID","@value":"9000254621399"},{"@type":"NRID","@value":"9000253625688"},{"@type":"NRID","@value":"9000253580733"},{"@type":"NRID","@value":"9000253596957"},{"@type":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Takayasu"},{"@language":"ja","@value":"白日, 高歩"},{"@language":"ja-Kana","@value":"シラクサ, タカヤス"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Surgery, Fukuoka University, School of Medicine"},{"@language":"ja","@value":"福岡大学医学部外科第二"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0016254X"},{"@type":"NCID","@value":"AN00215478"}],"prism:publicationName":[{"@language":"ja","@value":"福岡醫學雜誌"},{"@language":"en","@value":"Fukuoka Acta Medica"}],"dc:publisher":[{"@value":"Fukuoka Medical Association"},{"@value":"福岡医学会"}],"prism:publicationDate":"1999-06-25","prism:volume":"90","prism:number":"6","prism:startingPage":"286","prism:endingPage":"294"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_14cb","dc:rights":["本資料は権利関係や内容に配慮し、本文を非公開にしています。閲覧をご希望の場合は冊子体をご利用ください。","Due to considerations regarding rights and content, the full text is not available for public access.. Please use the printed version.","『福岡医学雑誌』の利用について","Regarding the Use of \"Fukuoka Acta Medica\""],"url":[{"@id":"https://search.jamas.or.jp/link/ui/2000030232"}],"foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Fas","dc:title":"Fas"},{"@id":"https://cir.nii.ac.jp/all?q=nicotinic%20acetylcholine%20receptor","dc:title":"nicotinic acetylcholine receptor"},{"@id":"https://cir.nii.ac.jp/all?q=myasthenia%20gravis","dc:title":"myasthenia gravis"},{"@id":"https://cir.nii.ac.jp/all?q=thymic%20epithelial%20cells","dc:title":"thymic epithelial cells"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"Fas"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"nicotinic acetylcholine receptor"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"myasthenia gravis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"thymic epithelial cells"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781600831488","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"04670506"},{"@type":"JGN","@value":"JP04670506"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04670506/"}],"notation":[{"@language":"ja","@value":"脾臓におけるニコチン性アセチルコリン受容体の構造と機能に関する研究"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1060307889983799297","@type":"Product","relationType":["references"]},{"@id":"https://cir.nii.ac.jp/crid/1970304959786619070","@type":"Book","resourceType":"雑誌(journal)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"福岡醫學雜誌 = Hukuoka acta medica : Hukuoka-igaku-zassi"},{"@language":"ja-Kana","@value":"フクオカ イガク ザッシ"}]}],"dataSourceIdentifier":[{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01211:0007255118"}],"dcterms:tableOfContents":[{"language":"en","dcterms:title":["Introduction / Patients and methods / Results / Discussion"]}]}