[Updated on July 12] Integration of CiNii Articles into CiNii Research from April 1, 2022

The particularities of placental morphogenesis within pregnant women, suffering from lung tuberculosis

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  • 結核合併妊娠における胎盤の形態学的特徴

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Abstract

type:研究報告

結核は世界的に蔓延している感染症であり、患者数は2003年時にはロシア、日本、チェコの順である。更に深刻な問題として若年者に発症が多く、それゆえ妊婦が結核に感染し未治療のケースが多い。妊娠時における胎盤の虚血性変化は妊娠中毒症よりも結核に罹患した場合の方が強く、未治療の方が更に強い。これは胎盤の絨毛への血流障害、血管新生の障害が原因である。結核合併妊娠時に抗結核薬投与によって胎盤の虚血が改善される傾向にある。この度、病理組織学的見地からも抗結核薬による早期治療が胎盤の虚血改善に重要であると考えられた。

Tuberculosis is among the most wide-spread infectious diseases in the world. Patient number of tuberculosis is first Russia, second Japan, and third Czechoslovakia at 2003. Recently, as an important problem, patients of younger people are increasing. So, there are many pregnancies who are tuberculosis with no medication. Placental insufficiency is appeared stronger in tuberculosis than in toxemia. In cases of tuberculosis, compensation of placental insufficiency is realized by celluar and mixed mechanism of adaptation. It is characterized by three-dimensional density reduction of cytotrophiblast in contrast with pregnancies suffering from toxemia of pregnancy and in healthy pregnancies. Which follows that the most expressing pathomorphologic changes were in the placentas from patients suffered from active tuberculosis, who hadn't been treated during their pregnancy. The mechanism of the placental insufficiency origin is mainly concluded in breach vilii vascularisation and breach of the placental angiogenesis. So, we should treat pregnant women with medication who are suffering from lung tuberculosis immediately.

identifier:18

identifier:KJ00005058701

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