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ウイルス性神経・精神神経疾患の発症機序の解析 : ボルナ病ウイルス

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  • Analysis of Virus-related neurological and psychiatric diseases-Borna disease virus infection

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The clinical disease and histopathological changes of the central nervous system of rats infected with two related Boraa disease virus (BDV) variants, CRP3 (rat-adapted prototype variant) or CRNP5 (mouseadapted variant) in two different strains of newborn rats (Lewis rats and Fischer 344 rats) and adult immunodeficient nude rats were investigated. In addition, the clinical disease and histopathology of the central nervous system of the nursing mothers of the above mentioned infected pups were also observed. Compared to newborn rats inoculated with CRP3, newborn Lewis and Fischer 344 rats inoculated with CRNP5 had more severe and rapid neurological signs, with more severe histopathological changes, mainly in the hippocampus. There was no evidence of encephalitis in either CRP3 or CNRP5 infection. In CRNP5 infection, pyramidal neurons of the hippocampus showed severe degeneration by day 20 p. i.. In CRP3 infection, the dentate gyrus had been destroyed and replaced with the glial cells by 6 weeks after inoculation. While, the dentate gyrus was intact by day 20 p. i.. Nude rats also showed the same tendency as the infected newborn rats, in neurological signs and histopathology of the brain for CRP3 and CRNP5. CRNP5-inoculated nude rats showed severe neurological signs by day 35-36 p. i. with severe neurological lesions in the hippocampus. On the other hand, CRP3-inoculated nude rats showed no apparent neurological signs by day 53 p. i., but with the degeneration of the neurons in the dentate gyrus and the pyramidal neurons of the hippocampus. Only one nursing mother of the CRNP5 infected newborn rats had nonsuppurative meningoencephalitis by 8 weeks. BDV-infected cells were identified by immunohistochemistry for BDV antigens. The antigens were detected mainly in the nuclei of the neurons of the dentate gyrus and the pyramidal neurons of the hippocampus. In the brain sample, virus titers were 1.2x10^7 TCID_<50>/g.




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