【7/12更新】2022年4月1日からのCiNii ArticlesのCiNii Researchへの統合について

ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 : 第二報.ラットにおけるニバレノールの吸収,代謝,排泄および毒性について

書誌事項

タイトル別名
  • STUDIES ON METABOLISM AND TOXICITIES OF NIVALENOL (MYCOTOXIN) : Ⅱ. ABSORPTION, METABOLISM, EXCRETION, AND TOXICITIES OF NIVALENOL IN RATS

この論文をさがす

抄録

type:Article

Absorption, distribution, and excretion of nivalenol and its major metabolite, deepoxynivalenol, were invesitigated in male rats after a single intraperitoneal (1 mg/Kg) or oral (5 mg/Kg) administration. After intraperitoneal administration, nivalenol and deepoxynivalenol excreted by the rats in urine were 48.3% and 3.8% of the total dose given respectively, and those excreted in feces were 10.0% and 25.5% of the dose, respectivly, within 72 hr. On the contrary, in oral administration, nivalenol and deepoxynivalenol excreted in urine were 9.9% and 5.6% of the dose, respectively, and those excreted in feces were 5.4% and 18.7% of the dose, respectively, in 72 hr. Deepoxynivalenol was excreted in feces to a higher extent than in urine and later than nivalenol. The levels of nivalenol detected in serum, liver and kidney were much lower than in urine or feces even 1 hr after oral dosing and were rapidly lowered. Deepoxynivalenol was not detected in serum, liver, or kidney at any time within 24 hr. The major metabolic pathways of nivalenol in rats are considered to be the deepoxidation at 12, 13-epoxide ring in the gastrointestine. The effect of feeding diets containing 0, 10, and 50 μg/g of nivalenol for 8 weeks on the growth rate, hematology, and histopathology were also examined. In 50 μg/g nivalenol dosing group, body-weight gain was significantly reduced and weak erythrocytopenia was observed. Histopathologically, mucosal necrosis and the disruption of gut epithelium, and an increase of erythroid series in bone marrow was observed. However, in 10 μg/g nivalenol dosing group, no significant change was observed in comparison with the control group.

identifier:奈良医学雑誌 Vol.41 No.4 p.335-343

identifier:04695550

identifier:13450069

identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2054

identifier:奈良医学雑誌, 41(4): 335-343

収録刊行物

関連論文

もっと見る

関連研究データ

もっと見る

関連図書・雑誌

もっと見る

関連博士論文

もっと見る

関連プロジェクト

もっと見る

関連その他成果物

もっと見る

詳細情報

ページトップへ