A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis
- Institute of Tropical Medicine, Nagasaki University
A simple and reproducible screening method of macrofilaricides is described. The method evaluated in the present paper is based on inhibitory activity of the drugs on acid-phosphatase of Dirofilaria immitis adult worms. The potent inhibitor of acid-phosphates, NaF, inhibited completely the enzymic activity at 1 mM. trimelarsan, suramin and flubendazole inhibited partially the enzymic activity. Their inhibitory activity is comparable to that of Na_2HAsO_4, a specific inhibitor of phosphatase. Diethylcarbamazine and levamisole did not inhibit the phosphatase of D. immitis.
identifier:熱帯医学 Tropical medicine 40(2). p95-97, 1998
- 熱帯医学 Tropical medicine
熱帯医学 Tropical medicine 40 (2), 95-97, 1998-10-30