【2022年1月締切】CiNii ArticlesへのCiNii Researchへの統合に伴う機関認証の移行確認について

【1/6更新】2022年4月1日からのCiNii ArticlesのCiNii Researchへの統合について

Higher exercise tolerance early after allogeneic hematopoietic stem cell transplantation is the predictive marker for higher probability of later social reintegration

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  • 濱田, 涼太
    Rehabilitation Unit, Kyoto University Hospital; Department of Physical Therapy, Graduate School of Health Science, Kibi International University
  • 新井, 康之
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University; Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University
  • 近藤, 忠一
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
  • 原田, 和宏
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
  • 村尾, 昌信
    Rehabilitation Unit, Kyoto University Hospital; Department of Physical Therapy, Graduate School of Health Science, Kibi International University
  • 宮坂, 淳介
    Rehabilitation Unit, Kyoto University Hospital
  • 吉田, 路子
    Rehabilitation Unit, Kyoto University Hospital
  • 米澤, 穂波
    Rehabilitation Unit, Kyoto University Hospital
  • 南角, 学
    Rehabilitation Unit, Kyoto University Hospital
  • 大内, 紗也子
    Nursing Department, Kyoto University Hospital
  • 北久保, 和加子
    Nursing Department, Kyoto University Hospital
  • 和田山, 智子
    Nursing Department, Kyoto University Hospital
  • 諫田, 淳也
    Department of Hematology and Oncology, Graduate School of Medicine
  • 高折, 晃史
    Department of Hematology and Oncology, Graduate School of Medicine
  • 池口, 良輔
    Rehabilitation Unit, Kyoto University Hospital
  • 松田, 秀一
    Rehabilitation Unit, Kyoto University Hospital

抄録

As the proportion of long-term survivors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is on the rise, it is essential to consider the significance of quality of life (QOL), including reintegration with society (returning to school or work). This retrospective cohort study aims to illustrate the precise epidemiology of social reintegration later after allo-HSCT and determine its predictive indicators. We enrolled 56 patients, and 40 patients (71%) attained social reintegration at 2 years post-HSCT. Reintegration failure markedly correlated with an inferior performance status and concurrent chronic graft-versus-host disease. In non-reintegrated patients, the physical function at discharge measured by the 6-min walking distance (6MWD) was markedly decreased. On the multivariate risk analyses, sex (female; odds ratio (OR) 0.07; 95% confidence interval (CI) 0.01–0.54; p = 0.01), HCT-CI (≥ 2; OR 0.10; 95% CI 0.01–0.84; p = 0.03), and change in 6MWD (per 5% increase; OR 1.47; 95% CI 1.01–2.13; p = 0.04) were significant predictors of later social reintegration. This study suggests that a multidisciplinary strategy including rehabilitation is essential, especially in patients with poor predictive markers at an early phase, and we should consider suitable rehabilitation programs to prevent a decline in exercise tolerance and improve social reintegration and overall QOL in patients after allo-HSCT.

同種造血幹細胞移植後における社会復帰の予測因子を発見 --移植後リハビリテーションがもつ重要性--. 京都大学プレスリリース. 2021-04-09.

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詳細情報

  • CRID
    1050287827461898240
  • HANDLE
    2433/262586
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
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