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Perphenazineの薬理学的研究(<特集>脳と神経の研究II)

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タイトル別名
  • PHARMACOLOGICAL PROPERTIES OF PERPHENAZINE
  • 原著
  • Original Article

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The effects of perphenazine have been determined in various preparations, and the following properties were noted : 1) Intraperitoneal (in cats) and per oral (in monkeys) administrations of doses from 2.5 to 5mg/kg of perphenazine induced effective sedation in the animals. 2) In rabbits and cats, arterial blood pressure was decreased by intravenous injection of 0.5mg/kg or more of perphenazine. 3) Administration of perphenazine in doses from 0.2 to 1 mg per animal into the lateral ventricle produced less decrease of blood pressure in rabbits as compared with the case of intravenous injection of the drug. 4) Perphenazine showed a potent adrenolytic action in blood pressure and in contraction of the nictitating membrane of cats. 5) Anti-acetylcholine property of perphenazine was observed in frog rectus muscle or isolated mouse ileum preparations, but the potency was a little less than the action of chlorpromazine. 6) As chlorpromazine, perphenazine possesses an autonomic ganglionic blocking action, as seen in the recording of postganglionic potentials of the superior cervical ganglion of cats. 7) Perphenazine depressed the cat's spinal cord reflex potentials; however the action was not seen in the spinal preparation. 8) Perphenazine has no depressant effect on the neuromuscular transmission of rabbits and rats. 9) Onset of the convulsion induced by pentylenetetrazol or strychnine in mice was not changed by pretreatment of perphenazine; however the time of death was apparently prolonged. 10) In electrocorticogram of cats, the arousal response induced by acoustic stimuli was effectively suppressed by perphenazine.

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