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Dementia and memory improvement due to histological changes in the brain hippocampus and hormone secretion of brain by lecithin administration

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Abstract : In this study, senescence accelerated mice (SAMP8 male, 8w), were used for the study of spatial recognition ability. We studied the effects on the brain hippocampus by administering lecithin (500 mg/kg, po). As compared to sham control group, the peroxy radical was inhibited significant in the lecithin administration group. The brain peroxidized fat level had a tendency to decrease was found in the lecithin group. Also, in the intracerebral serotonin concentration, was increased in the sham control more than the lecithin administration group (referred to as the lecithin group thereafter). It was found that the delivery time was shortened in the water maze experiment of the lecithin group as compared to the sham control. Furthermore, activation of pyramidal cells in the CA1 region of the hippocampus was observed in the lecithin group. Therefore, a peroxy radical was extinguished in this study by lecithin intake, and lipid hydroperoxides in brain of the SAM (Senescence-Accelerated Mouse) mouse were decreased by the lecithin administration. Also, it was found that lipid peroxidation of the brain was inhibited. Furthermore, hippocampal nerve cells were activated as suggested thus cognitive function was improved. Also, intracerebral serotonin concentration was normalized so we can expect effect for the affective disorders that were demented peripheral symptom by homeostatic effect. It is because lipid peroxidation inhibition, learning and effect for the improvement effect of the memory impairment were found by a lecithin administration, it was found that the lecithin was effective in the memory improvement in dementias as well.

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