The combination of Type 2 Diabetes Mellitus (T2DM) and Non-Alcoholic Fatty Liver Disease (NAFLD) has been a crucial problem. NAFLD means wide from Hepatic Steatosis (HS) to Nonalcoholic Steatohepatitis (NASH). NAFLD may be the predictor of causing Cardiovascular Disease (CVD). A dynamic association is found between NAFLD and Hepatic Insulin Resistance (IR). Treatments for T2DM and NAFLD include Glucagon-Like Peptide 1 Receptor Agonist (GLP-1 RA), Dipeptidyl-Peptidase 4 Inhibitors (DPP-4i) and Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i). An advanced NASH-specific agent is the Farnesoid X Receptor (FXR) agonist Obeticholic Acid (OCA). Further development of research and pharmaceutical industry will be expected.