Towards single particle imaging of human chromosomes at SACLA
type:学術雑誌論文 Journal Article
Robinson I., Schwenke J., Yusuf M., et al. Towards single particle imaging of human chromosomes at SACLA. Journal of Physics B: Atomic, Molecular and Optical Physics, 48, 24, 244007. https://doi.org/10.1088/0953-4075/48/24/244007.
Single particle imaging (SPI) is one of the front-page opportunities which were used to motivate the construction of the first x-ray free electron lasers (XFELs). SPI's big advantage is that it avoids radiation damage to biological samples because the diffraction takes place in femtosecond single shots before any atomic motion can take place in the sample, hence before the onset of radiation damage. This is the 'diffract before destruction' theme, destruction being assured from the high x-ray doses used. This article reports our collaboration's first attempt at SPI using the SACLA XFEL facility in June 2015. The report is limited to experience with the instrumentation and examples of data because we have not yet had time to invert them to images.
- Journal of Physics B: Atomic, Molecular and Optical Physics
Journal of Physics B: Atomic, Molecular and Optical Physics 48 (24), 244007-, 2015-11-03
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