- A Literature Review of Reported Cases of Mesenteric Phlebosclerosis Caused by Herbal Medicine Containing Gardenia Fruit
Mesenteric phlebosclerosis（MP）is a rare disease characterized by mesenteric vein calcification and venous congestion of the colon. The first case was reported in 1991, but the etiology of the disease remains unclear. recently, however, the long-term intake of herbal medicine containing gardenia fruit（GF, sanshishi in Japanese）has been reported to cause MP. in this review, we searched the PubMed and Ichushi databases for published case reports of MP with a history of GF use and reviewed the clinical characteristics of the cases. in total, 236 cases of MP were collected from 170 articles, and 84 had a history of GF use. Patients ranged in age from 31 to 87（mean, 63.5）years, with a male to female ratio of nearly 1 : 2. Seventy-nine of the 84 patients were Japanese. Subjective symptoms were present in 70% of cases, including abdominal pain, nausea and vomiting, and diarrhea. kamishoyosan（33/84, 39.3%）and Orengedokuto（27/84, 32.1%）were the most frequently used herbal medicines containing GF. The median dosing period to onset of MP was 12 years, and 92.6% of the patients had been taking GF for more than 5 years. Multiple case reports showed that the risk of onset increased when the cumulative dose of GF was 5,000 g or more. Therefore, endoscopy should be performed if the cumulative dose exceeds 5,000 g, even if the patient is asymptomatic.
- 東北医科薬科大学研究誌 = Journal of Tohoku medical and Pharmaceutical university
東北医科薬科大学研究誌 = Journal of Tohoku medical and Pharmaceutical university 67 47-60, 2020-12