【7/12更新】2022年4月1日からのCiNii ArticlesのCiNii Researchへの統合について

Extreme deformability of insect cell membranes is governed by phospholipid scrambling

HANDLE オープンアクセス
  • 塩見, 晃史
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 長尾, 耕治郎
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 横田, 展大
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 土谷, 正樹
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 加藤, 詩子
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 従二, 直人
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 原, 雄二
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 森, 誠之
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 森, 泰生
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
  • 程, 久美子
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo
  • 村手, 源英
    UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg
  • 小林, 俊秀
    UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg
  • 西野, 有里
    Graduate School of Life Science, University of Hyogo
  • 宮澤, 淳夫
    Graduate School of Life Science, University of Hyogo
  • 山本, 暁久
    Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University
  • 鈴木, 量
    Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University
  • Kaufmann, Stefan
    Physical Chemistry of Biosystems, Institute of Physical Chemistry, University of Heidelberg
  • 田中, 求
    Center for Integrative Medicine and Physics, Institute for Advanced Study, Kyoto University; Physical Chemistry of Biosystems, Institute of Physical Chemistry, University of Heidelberg
  • 巽, 和也
    Department of Mechanical Engineering and Science, Kyoto University
  • 中部, 主敬
    Department of Mechanical Engineering and Science, Kyoto University
  • 新宅, 博文
    Microfluidics RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research
  • Yesylevsky, Semen
    Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté; Department of Physics of Biological Systems, Institute of Physics of the National Academy of Sciences of Ukraine
  • Bogdanov, Mikhail
    Department of Biochemistry & Molecular Biology, University of Texas Health Science Center at Houston, McGovern Medical School
  • 梅田, 眞郷
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University; Present address: HOLO BIO Co., Ltd

抄録

Organization of dynamic cellular structure is crucial for a variety of cellular functions. In this study, we report that Drosophila and Aedes have highly elastic cell membranes with extremely low membrane tension and high resistance to mechanical stress. In contrast to other eukaryotic cells, phospholipids are symmetrically distributed between the bilayer leaflets of the insect plasma membrane, where phospholipid scramblase (XKR) that disrupts the lipid asymmetry is constitutively active. We also demonstrate that XKR-facilitated phospholipid scrambling promotes the deformability of cell membranes by regulating both actin cortex dynamics and mechanical properties of the phospholipid bilayer. Moreover, XKR-mediated construction of elastic cell membranes is essential for hemocyte circulation in the Drosophila cardiovascular system. Deformation of mammalian cells is also enhanced by the expression of Aedes XKR, and thus phospholipid scrambling may contribute to formation of highly deformable cell membranes in a variety of living eukaryotic cells.

昆虫の細胞は柔らかい! --細胞膜を柔らかくするタンパク質を発見--. 京都大学プレスリリース. 2021-06-09.

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詳細情報

  • CRID
    1050851398241081728
  • HANDLE
    2433/263314
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
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