【2022年1月締切】CiNii ArticlesへのCiNii Researchへの統合に伴う機関認証の移行確認について

【1/6更新】2022年4月1日からのCiNii ArticlesのCiNii Researchへの統合について

Molecular aspects of poliovirus pathogenesis

  • NOMOTO Akio
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo

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The development of a transgenic mouse model carrying the human poliovirus receptor has made it possible to investigate the molecular mechanisms of the viral dissemination process in a whole organism. Studies on this have provided an insight into the mechanisms for viral permeation through the blood-brain barrier and retrograde axonal transport of the virus. In addition, strain-specific neurovirulence levels are shown to depend mainly on the replicating capacity of the virus in the central nervous system rather than the efficiency of the 2 dissemination pathways indicated above. Studies of poliovirus-induced cytopathic effects on neural cells revealed that neural cells possess anti-poliovirus characteristics that may offer a new avenue for investigating the molecular mechanisms of poliovirus neurovirulence.<BR><BR>(Communicated by Kumao TOYOSHIMA, M.J.A.

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