【2022年1月締切】CiNii ArticlesへのCiNii Researchへの統合に伴う機関認証の移行確認について

【1/6更新】2022年4月1日からのCiNii ArticlesのCiNii Researchへの統合について

がん疼痛に対しオキシコドン導入となった患者におけるポリファーマシーの実態調査

書誌事項

タイトル別名
  • Research on Polypharmacy in Patients with Oxycodone Introduction for Cancer Pain

抄録

<p>Patients with cancer pain tend to be engaged in polypharmacy, using cancer treatments, analgesics, and supportive therapy drugs for side effects. We retrospectively examined patients on opioids and actual state of polypharmacy.</p><p>Oral oxycodone was introduced in 85 inpatients in Nagoya University Hospital between April 1 2011 and March 31 2012. The number of daily oral drugs before/after oxycodone introduction was researched. Drugs were classified by purpose of use. Risk factors for polypharmacy were determined using univariate and multivariate analysis. Drug-drug interactions and points of note on attached documents about driving were examined. Depending on the number of oral drugs after oxycodone introduction, patients were classified into 3 groups, 0-4 drugs (non-polypharmacy: NP group), 5-9 drugs (polypharmacy: P group), higher than 10 drugs (hyper-polypharmacy: HP group). Median value was 8 drugs after oxycodone introduction, but 4 drugs before introduction. NP group, P group and HP group contain 6, 58 and 21 patients each. The number of drugs tended to increase more in aging, number of diseases, and shift to best supportive care (BSC) (P < 0.05). One drug (0-6 drugs) had drug-drug interaction in the median. Three drugs (1-9 drugs) were required attention for driving, and increased in 3 groups significantly (P < 0.001). In patients on oxycodone, aging, increase in the number of comorbidities, and shift to cancer end-of-life become the risk factors of polypharmacy. It is suggested that polypharmacy increases the risk of drug adverse effects, and continuous assessment of oral drugs is required in future.</p>

収録刊行物

  • 医療薬学

    医療薬学 45 (6), 322-330, 2019-06-10

    一般社団法人日本医療薬学会

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