- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Hyaluronic acid and its derivative as a multi-functional gene expression enhancer: Protection from non-specific interactions, adhesion to targeted cells, and transcriptional activation
Bibliographic Information
- Other Title
-
- Hyaluronic acid and its derivative as a multi‐functional gene expression enhancer: Protection from non‐specific interactions, adhesion to targeted cells, and transcriptional activation
Search this article
Description
Hyaluronic acid (HA), a natural anionic mucopolysaccharide, can be deposited onto the cationic surface of DNA/polyethyleneimine (PEI) complexes to recharge the surface potential and reduce nonspecific interactions with proteins. HA can also be used as a ligand to target specific cell receptors. Furthermore, HA-coating enhanced the transcriptional activity of the plasmid/PEI complexes, probably by loosening the tight binding between DNA and PEI, which facilitated the approach of transcription factors. Amphoteric HA derivative having spermine side chains (Spn-HA) with a structure similar to HMG protein showed higher transcription-enhancing activity than HA. Plasmid/PEI/Spn-HA ternary complex exhibited 29-fold higher transgene expression efficiency than naked plasmid/PEI complexes in CHO cells.
Journal
-
- Journal of Controlled Release
-
Journal of Controlled Release 112 (3), 382-388, 2006-05
Elsevier
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1050001201936193024
-
- NII Article ID
- 120000896370
-
- NII Book ID
- AA10458678
-
- ISSN
- 01683659
-
- HANDLE
- 2433/49171
-
- PubMed
- 16647780
-
- Text Lang
- en
-
- Article Type
- journal article
-
- Data Source
-
- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE