イヌ顎裂モデルを用いた上顎歯槽骨延長術後の歯髄血流量および硬組織変化の観察

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  • 青木 朝里
    東京医科歯科大学大学院医歯学総合研究科 顎顔面頸部機能再建学系専攻 顎顔面機能修復学講座 顎顔面矯正学分野

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タイトル別名
  • Observation of Pulpal Blood Flow and Bone Mineralization after Alveolar Distraction Osteogenesis in a Canine Cleft Model
  • イヌ ガクレツモデル オ モチイタ ウワアゴ シソウコツ エンチョウ ジュツゴ ノ シズイ ケツ リュウリョウ オヨビ コウソシキ ヘンカ ノ カンサツ

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<p>  Objective : Distraction osteogenesis has been widely used for the craniofacial region and even applied to alveolar bones to reduce the cleft width of cleft lip and/or palate patients. However, there have been no reports on the limitations on the total amount of lengthening that can be accomplished by distraction osteogenesis in this area. Therefore, we investigated how different extents of distraction osteogenesis affect the healing process using a canine cleft palate model.</p><p>  Methods : Six beagle dogs were used in this study. A bony segment including the canine was prepared and translocated into a 10-mm bone defect area, imitating a cleft, at a rate of 1 mm/day for six or ten days, resulting in two groups (6- and 10-mm groups). Canine pulpal blood flow was monitored for 100 days by Doppler flowmetry. The animals were then sacrificed and the regenerated bone area was evaluated using peripheral quantitative computed tomography (pQCT) and a histological process. Statistical significance was confirmed by the Mann-Whitney rank sum test.</p><p>  Results : Pulpal blood flow recovered to the original levels significantly earlier in the 6-mm group. It was shown by pQCT evaluation that cortical bone density in the regenerated bone was significantly higher in the 6-mm group. The amount of regenerated bone in histological sections was also significantly higher in the 6-mm group than in the 10-mm group.</p><p>  Conclusion : We revealed that the amount of bone lengthening affects the progress of healing. These results suggest the importance of limited distraction osteogenesis in the maxillofacial area.</p>

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