-
- Nobuo Okahashi
- Department of Oral and Molecular Microbiology Osaka University Graduate School of Dentistry Suita, Osaka Japan
-
- Masanobu Nakata
- Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan
-
- Hirotaka Kuwata
- Department of Oral Microbiology and Immunology, School of Dentistry Showa University Shinagawa, Tokyo Japan
-
- Shigetada Kawabata
- Department of Oral and Molecular Microbiology Osaka University Graduate School of Dentistry Suita, Osaka Japan
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Members of the oral mitis group streptococci including <jats:italic>Streptococcus oralis, Streptococcus sanguinis</jats:italic>, and <jats:italic>Streptococcus gordonii</jats:italic> are the most abundant inhabitants of human oral cavity and dental plaque, and have been implicated in infectious complications such as bacteremia and infective endocarditis. Oral mitis group streptococci are genetically close to <jats:italic>Streptococcus pneumoniae</jats:italic>; however, they do not produce cytolysin (pneumolysin), which is a key virulence factor of <jats:italic>S. pneumoniae</jats:italic>. Similar to <jats:italic>S. pneumoniae</jats:italic>, oral mitis group streptococci possess several cell surface proteins that bind to the cell surface components of host mammalian cells. <jats:italic>S. sanguinis</jats:italic> expresses long filamentous pili that bind to the matrix proteins of host cells. The cell wall–anchored nuclease of <jats:italic>S. sanguinis</jats:italic> contributes to the evasion of the neutrophil extracellular trap by digesting its web‐like extracellular DNA. Oral mitis group streptococci produce glucosyltransferases, which synthesize glucan (glucose polymer) from sucrose of dietary origin. Neuraminidase (NA) is a virulent factor in oral mitis group streptococci. Influenza type A virus (IAV) relies on viral NA activity to release progeny viruses from infected cells and spread the infection, and NA‐producing oral streptococci elevate the risk of IAV infection. Moreover, oral mitis group streptococci produce hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) as a by‐product of sugar metabolism. Although the concentrations of streptococcal H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> are low (1–2 mM), they play important roles in bacterial competition in the oral cavity and evasion of phagocytosis by host macrophages and neutrophils. In this review, we intended to describe the diverse pathogenicity of oral mitis group streptococci.</jats:p>
収録刊行物
-
- Microbiology and Immunology
-
Microbiology and Immunology 66 (12), 539-551, 2022-10-04
Wiley
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1360580229799454720
-
- ISSN
- 13480421
- 03855600
-
- データソース種別
-
- Crossref
- KAKEN