Crucial role of TFAP2B in the nervous system for regulating NREM sleep

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<jats:title>Abstract</jats:title><jats:p>The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2β (TFAP2B) reduces non-rapid eye movement (NREM) sleep. When and where TFAP2B functions, however, is unclear. Here, we used the Cre-loxP system to generate mice in which <jats:italic>Tfap2b</jats:italic> was specifically deleted in the nervous system during development and mice in which neuronal <jats:italic>Tfap2b</jats:italic> was specifically deleted postnatally. Both types of mice exhibited reduced NREM sleep, but the nervous system-specific deletion of <jats:italic>Tfap2b</jats:italic> resulted in more severe sleep phenotypes accompanied by defective light entrainment of the circadian clock and stereotypic jumping behavior. These findings indicate that TFAP2B in postnatal neurons functions at least partly in sleep regulation and imply that TFAP2B also functions either at earlier stages or in additional cell types within the nervous system.</jats:p>

収録刊行物

  • Molecular Brain

    Molecular Brain 17 (1), 2024-02-27

    Springer Science and Business Media LLC

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