From the Department of Clinical and Molecular Cardiovascular Research (K.I., K.M., H.Y., N.M., T.S., T.U., R.W., R.K., M.I.) and the Department of Cardiology (K.I., K.M., H.Y., N.M., T.S., Y.K., R.K., K.F., M.I.), Keio University School of Medicine, and JST, CREST, Tokyo, Japan; RIKEN Bio Resource Center, Gene Engineering Division, Tsukuba, Japan (K.N., C.K., Y.O.); and the Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan (K.M.). (At 2012-10-12)