Elucidation of the sleep-inducing neuronal system

KAKEN

About This Project

Japan Grant Number
JP15K18359 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
15K18359
Research Category
Grant-in-Aid for Young Scientists (B)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences > Biological Sciences > Neuroscience > Nerve anatomy/Neuropathology
Research Institution
  • University of Tsukuba
Project Period (FY)
2015-04-01 〜 2018-03-31
Project Status
Completed
Budget Amount*help
3,900,000 Yen (Direct Cost: 3,000,000 Yen Indirect Cost: 900,000 Yen)

Research Abstract

The mechanism of sleep-wake control by motivation is unclear. We discovered a sleep increasing effect through the ventral pallidum of the basal forebrain by selective activation of the adenosine A2A receptor expressing neurons of the nucleus accumbens in the basal ganglia. Motivational stimuli decreased the activity of the nucleus accumbens A2A receptor neurons that project to the ventral pallidum, and the sleep amount was decreased accordingly. These results indicate that the nucleus accumbens and ventral pallidum have important roles in motivation-related sleep regulation.

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