Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method
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- Ishii Yuji
- Principal Investigator
- 九州大学
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- 廣田 有子
- Co-Investigator
- 九州大学
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- 宮内 優
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP17H00788
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17H00788
- Research Category
- Grant-in-Aid for Scientific Research (A)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Integrated Disciplines > Environmental science > Environmental analyses and evaluation > Environmental impact assessment
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2017-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 43,030,000 Yen (Direct Cost: 33,100,000 Yen Indirect Cost: 9,930,000 Yen)
Research Abstract
In this study, we considered dioxins as a chemical substance capable of disturbing both the internal and external environments. We examined the adverse effects of dioxins evoked on the next generation by using pregnant rats and mice, aiming to develop a safe and efficient preventive method toward these substances’ undesirable effects. DAPL1 was identified as an important gene for reducing growth hormone at critical period. Then, Dapl1-deficient mice were constructed and are continuously being used for further research and characterization. We comprehensively investigated UGT in rats and mice, identified the major isoform involved in glucocorticoid conjugation. In addition, the hetero-knockout mice have been established. Further, we showed that lipoic acid-enriched diet until weaning is effective to improve sexual immaturity at puberty. Finally, with regards to prolactin’s decrease in the dams, we were also able to elucidate the decrease in milk yield for the second next generation.