Identification of higher-order-epigenetic modification machineries and development of potential novel therapeutics in severe virus infection
-
- Imai Yumiko
- Principal Investigator
- 国立研究開発法人医薬基盤・健康・栄養研究所
-
- 久場 敬司
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP17H06179
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17H06179
- Research Category
- Grant-in-Aid for Scientific Research (S)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Biological Sciences > Medicine, Dentistry, and Pharmacy > Clinical surgery > Emergency medicine
- Research Institution
-
- National Institutes of Biomedical Innovation, Health and Nutrition
- Project Period (FY)
- 2017-05-31 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 196,170,000 Yen (Direct Cost: 150,900,000 Yen Indirect Cost: 45,270,000 Yen)
Research Abstract
We examined the response of host chromatin structures upon viral infection with influenza virus and SARS-CoV2. We found that the host chromatin structure dynamically changes upon influenza virus infection. Suv4-20h2, a trimethyltransferase of H4K20 that binds to cohesin was involved in the maintenance of heterochromatin structure in the uninfected condition. Upon infection, cohesin was dissociated from Suv4-20h2 and loaded to the boundary of a specific genomic region, forming a chromatin loop, activating the gene expression in the region responsible for virus infection. Furthermore, using specimens from patients with COVID-19, we performed genome-wide host chromatin structure analysis and obtained the findings suggesting a link to the severity of the disease.
Details 詳細情報について
-
- CRID
- 1040000781959410176
-
- Text Lang
- ja
-
- Data Source
-
- KAKEN